| pubmed-article:9000040 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C0038304 | lld:lifeskim |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:9000040 | lifeskim:mentions | umls-concept:C0016132 | lld:lifeskim |
| pubmed-article:9000040 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:9000040 | pubmed:dateCreated | 1997-2-11 | lld:pubmed |
| pubmed-article:9000040 | pubmed:abstractText | We have studied the sera from 304 patients with insulin-dependent diabetes mellitus (IDDM) for steroid 21-hydroxylase (P450c21) autoantibodies by an in vitro translation and immunoprecipitation assay. Autoantibodies to P450c21 were found in 7 patients with IDDM (2.3%). When the IDDM patients with P450c21 antibodies were analyzed for their HLA, 6 of them (86%) belonged to the HLA DQB1*0201-positive group. A strong correlation (r = 0.91, P < 0.001) of immunoprecipitation results was observed with adrenocortical autoantibodies detected by indirect immunofluorescence, indicating that the adrenal autoantibodies in patients with IDDM were anti-P450c21 autoantibodies. The levels of P450c21 autoantibodies were significantly higher (P < 0.05) in patients with IDDM than in 13 (9 P450c21 autoantibody positive) patients with Addison's disease. Although the occurrence of P450c21 antibodies in IDDM was relatively low, antibody-positive patients had high antibody levels and may have an ongoing subclinical process of adrenal autoimmunity. | lld:pubmed |
| pubmed-article:9000040 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9000040 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9000040 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9000040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9000040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9000040 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9000040 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9000040 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:KrohnKK | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:PetersonPP | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:MiettinenAA | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:IlonenJJ | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:AkerblomH KHK | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:SalmiHH | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:HyötyHH | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:KnipMM | lld:pubmed |
| pubmed-article:9000040 | pubmed:author | pubmed-author:ReijonenHH | lld:pubmed |
| pubmed-article:9000040 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9000040 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:9000040 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9000040 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9000040 | pubmed:pagination | 37-42 | lld:pubmed |
| pubmed-article:9000040 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:meshHeading | pubmed-meshheading:9000040-... | lld:pubmed |
| pubmed-article:9000040 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:9000040 | pubmed:articleTitle | Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Childhood Diabetes in Finland (DiMe) Study Group. | lld:pubmed |
| pubmed-article:9000040 | pubmed:affiliation | Institute of Medical Technology and University Hospital, University of Tampere, Finland. | lld:pubmed |
| pubmed-article:9000040 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9000040 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
