| pubmed-article:8997544 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8997544 | lifeskim:mentions | umls-concept:C0026339 | lld:lifeskim |
| pubmed-article:8997544 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:8997544 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8997544 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:8997544 | lifeskim:mentions | umls-concept:C0870071 | lld:lifeskim |
| pubmed-article:8997544 | lifeskim:mentions | umls-concept:C0205430 | lld:lifeskim |
| pubmed-article:8997544 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8997544 | pubmed:dateCreated | 1997-3-14 | lld:pubmed |
| pubmed-article:8997544 | pubmed:abstractText | There is no method available to compare the fit of two non-hierarchical non-linear mixed effects models, although the common practice is to select the model with the lower objective function. Bootstrapping the log-likelihood differences (LLDs) of non-hierarchical models and constructing a bootstrap confidence interval on the LLDs is proposed for comparing the goodness-of-fit of such models. This is illustrated with different parameterizations of clearance models for an anti-infective agent in a longitudinal pharmacokinetic study which are compared. Additive and exponential models of creatinine clearance as a predictor of clearance are used as examples. | lld:pubmed |
| pubmed-article:8997544 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8997544 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8997544 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8997544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8997544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8997544 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8997544 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8997544 | pubmed:issn | 0010-4825 | lld:pubmed |
| pubmed-article:8997544 | pubmed:author | pubmed-author:EtteE IEI | lld:pubmed |
| pubmed-article:8997544 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8997544 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:8997544 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8997544 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8997544 | pubmed:pagination | 505-12 | lld:pubmed |
| pubmed-article:8997544 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:meshHeading | pubmed-meshheading:8997544-... | lld:pubmed |
| pubmed-article:8997544 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8997544 | pubmed:articleTitle | Comparing non-hierarchical models: application to non-linear mixed effects modeling. | lld:pubmed |
| pubmed-article:8997544 | pubmed:affiliation | Office of Clinical Pharmacology and Biopharmaceutics, Food and Drug Administration, Rockville, MD 20857, USA. | lld:pubmed |
| pubmed-article:8997544 | pubmed:publicationType | Journal Article | lld:pubmed |
