| pubmed-article:8992967 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8992967 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8992967 | lifeskim:mentions | umls-concept:C0259309 | lld:lifeskim |
| pubmed-article:8992967 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8992967 | pubmed:dateCreated | 1997-2-11 | lld:pubmed |
| pubmed-article:8992967 | pubmed:abstractText | The interaction of the T cell surface protein CD28 with its ligand, B7-1 or B7-2, provides a critical costimulatory signal for T cell activation. T cells from CD28- mice are deficient in a variety of responses, including those to lectins and allogeneic spleen cells. However, some immune responses do occur in CD28- mice, suggesting the existence of alternate costimulatory pathways. In this work, we show that T cells purified from CD28- mice respond to B lymphomas expressing 4-1BB ligand (4-1BBL), a member of the TNF gene family. This response is inhibited by a soluble form of 4-1BB, the T cell surface receptor for 4-1BBL. Thus, 4-1BBL/4-1BB interaction provides costimulatory signals to T cells independent of signaling through the CD28 receptor. We find that 4-1BBL is inducible on splenic B cells by CD40 ligand/CD40 interaction or by culturing of splenic dendritic cells, treatments that also induce B7 family molecules. CD28- T cells fail to respond in an MLR to resting allogeneic spleen cells. However, treatment of spleen cells with CD40 ligand renders them competent in activation of CD28- T cells. In contrast to results using B lymphomas as APC, soluble 4-1BB fails to inhibit the T cell response to activated spleen cells. This failure of soluble 4-1BB to block an MLR between CD28+ or CD28- T cells and allogeneic spleen cells is in contrast to a previous report with CD28+ cells. | lld:pubmed |
| pubmed-article:8992967 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8992967 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8992967 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8992967 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8992967 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8992967 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8992967 | pubmed:author | pubmed-author:WattsT HTH | lld:pubmed |
| pubmed-article:8992967 | pubmed:author | pubmed-author:MaoT STS | lld:pubmed |
| pubmed-article:8992967 | pubmed:author | pubmed-author:ShahinianAA | lld:pubmed |
| pubmed-article:8992967 | pubmed:author | pubmed-author:DeBenedetteM... | lld:pubmed |
| pubmed-article:8992967 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8992967 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8992967 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:8992967 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8992967 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8992967 | pubmed:pagination | 551-9 | lld:pubmed |
| pubmed-article:8992967 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8992967 | pubmed:year | 1997 | lld:pubmed |
| pubmed-article:8992967 | pubmed:articleTitle | Costimulation of CD28- T lymphocytes by 4-1BB ligand. | lld:pubmed |
| pubmed-article:8992967 | pubmed:affiliation | Department of Immunology, University of Toronto, Canada. | lld:pubmed |
| pubmed-article:8992967 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8992967 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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