Integrins as promiscuous signal transduction devices.

Source:http://linkedlifedata.com/resource/pubmed/id/8991380

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General Info

Authors

Todd RF, Petty HR

Affiliation

Dept of Biological Sciences, Wayne State University, Detroit, MI 48202, USA.

Abstract

Recent studies suggest physical and functional interactions of glycosylphosphatidylinositol (GPI)-linked proteins (CD14, CD16b and CD87) with leukocyte beta 2 integrins. As discussed in this article, it now appears that beta 2 integrins relay proinflammatory information from GPI-anchored membrane receptors to the cytoplasm via exodomain interactions.

PMID
8991380

Publication types

Research Support, U.S. Gov't, P.H.S.; Review; Research Support, Non-U.S. Gov't