| pubmed-article:8988452 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8988452 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:8988452 | lifeskim:mentions | umls-concept:C0016365 | lld:lifeskim |
| pubmed-article:8988452 | lifeskim:mentions | umls-concept:C0031937 | lld:lifeskim |
| pubmed-article:8988452 | lifeskim:mentions | umls-concept:C0040805 | lld:lifeskim |
| pubmed-article:8988452 | lifeskim:mentions | umls-concept:C1269683 | lld:lifeskim |
| pubmed-article:8988452 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:8988452 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8988452 | pubmed:dateCreated | 1997-4-2 | lld:pubmed |
| pubmed-article:8988452 | pubmed:abstractText | Fluoxetine, a selective serotonin (5-HT) reuptake inhibitor (SSRI), and trazodone, a heterocyclic antidepressant, are effective in the treatment of major depression and treatment resistant depression (TRD). Chronic treatment with both drugs causes increases in extracellular 5-HT through 5-HT reuptake inhibition and desensitization of inhibitory 5-HT1A autoreceptors. It has been shown that pindolol, a serotonin (5-HT)1A-receptor antagonist, may shorten the latency of onset of SSRIs in depression. The aim of the present study was to examine whether pindolol may increase the efficacy of a subtherapeutical dosage of trazodone in the treatment of major depression and TRD, defined according to the Thase and Rush criteria (1995). Thirty-three major depressed inpatients of whom 26 with TRD participated in this study. Ten days after hospitalization, treatment with trazodone 100 mg/day was started. After 1 week trazodone treatment, patients were randomized-using a double blind placebo controlled design-to receive trazodone 100 mg/day+placebo; trazodone 100 mg/day+pindolol 7.5 mg/day: or trazodone 100 mg/day+fluoxetine 20 mg/day and treated during 4 weeks. The 17-item Hamilton Depression Rating Scale (HDRS) was used as outcome measure. It was found that trazodone+pindolol was as effective as trazodone+fluoxetine in the treatment of major depression and TRD and significantly more effective than trazodone+placebo. Using an outcome measure of 50% reduction in the HDRS, we found that 72.5% of the depressed patients treated with trazodone+pindolol and 75% of depressed patients treated with trazodone+fluoxetine showed a clinically significant response compared with 20.0% of trazodone+placebo-treated patients. | lld:pubmed |
| pubmed-article:8988452 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8988452 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8988452 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8988452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8988452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8988452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8988452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8988452 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8988452 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8988452 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8988452 | pubmed:issn | 0165-0327 | lld:pubmed |
| pubmed-article:8988452 | pubmed:author | pubmed-author:MaesMM | lld:pubmed |
| pubmed-article:8988452 | pubmed:author | pubmed-author:DesnyderRR | lld:pubmed |
| pubmed-article:8988452 | pubmed:author | pubmed-author:VandoolaegheE... | lld:pubmed |
| pubmed-article:8988452 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8988452 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:8988452 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:8988452 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8988452 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8988452 | pubmed:pagination | 201-10 | lld:pubmed |
| pubmed-article:8988452 | pubmed:dateRevised | 2009-9-28 | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
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| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:meshHeading | pubmed-meshheading:8988452-... | lld:pubmed |
| pubmed-article:8988452 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8988452 | pubmed:articleTitle | Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression. | lld:pubmed |
| pubmed-article:8988452 | pubmed:affiliation | Clinical Research Center Mental Health, University Department of Psychiatry, AZ Stuicenberg, Antwerp, Belgium. | lld:pubmed |
| pubmed-article:8988452 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8988452 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8988452 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8988452 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:8988452 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8988452 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8988452 | lld:pubmed |
