| pubmed-article:8986717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C0007590 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C1519877 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C1567709 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C2698932 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:8986717 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:8986717 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8986717 | pubmed:dateCreated | 1997-1-30 | lld:pubmed |
| pubmed-article:8986717 | pubmed:abstractText | The proteins RAG-1 and RAG-2 are essential for initiation of V(D)J recombination. In dividing cells, RAG-2 accumulates during G1 and is undetectable during the S and G2/M cell cycle phases. A conserved degradation signal, including an essential CDK phosphorylation site at Thr-490, regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. Mutations within this signal abolish periodic degradation of RAG-2 protein in dividing cells. In mice expressing endogenous or wild-type transgenic RAG-2, V(D)J recombination intermediates accumulate preferentially in G0/G1 thymocytes; this restriction is relieved by mutation of Thr-490 to alanine (T490A). Thus, periodic destruction of RAG-2 protein couples V(D)J recombination to cell cycle phase. Using transgenic mice expressing the T490A RAG-2 mutant and a functional T cell receptor beta chain, we demonstrate that coupling of V(D)J recombination to the cell cycle is not essential for enforcement of allelic exclusion. | lld:pubmed |
| pubmed-article:8986717 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8986717 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8986717 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8986717 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:8986717 | pubmed:author | pubmed-author:LeeJJ | lld:pubmed |
| pubmed-article:8986717 | pubmed:author | pubmed-author:MASS | lld:pubmed |
| pubmed-article:8986717 | pubmed:author | pubmed-author:DesiderioSS | lld:pubmed |
| pubmed-article:8986717 | pubmed:author | pubmed-author:DordaiD IDI | lld:pubmed |
| pubmed-article:8986717 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8986717 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:8986717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8986717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8986717 | pubmed:pagination | 575-89 | lld:pubmed |
| pubmed-article:8986717 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:meshHeading | pubmed-meshheading:8986717-... | lld:pubmed |
| pubmed-article:8986717 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8986717 | pubmed:articleTitle | A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. | lld:pubmed |
| pubmed-article:8986717 | pubmed:affiliation | Department of Molecular Biology and Genetics, John Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. | lld:pubmed |
| pubmed-article:8986717 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8986717 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8986717 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19374 | entrezgene:pubmed | pubmed-article:8986717 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986717 | lld:pubmed |
