| pubmed-article:8986607 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C1326471 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C1526989 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C0533999 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8986607 | lifeskim:mentions | umls-concept:C0949374 | lld:lifeskim |
| pubmed-article:8986607 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8986607 | pubmed:dateCreated | 1997-2-6 | lld:pubmed |
| pubmed-article:8986607 | pubmed:abstractText | Many nuclear proteins are imported into the cell nucleus by the "classical" nuclear localization signal (NLS)-mediated import pathway. In this pathway, a sequence rich in basic residues in the protein interacts with a heterodimeric complex termed importin and this, along with the GTPase Ran, mediates nuclear import of the NLS-bearing protein. The heterogeneous nuclear ribonucleoprotein (hnRNP) A1 protein contains a novel nuclear localization sequence, termed M9, that does not contain any clusters of basic residues. Very recently, we showed that M9 directs import into the nucleus by a novel protein import pathway distinct from the classical NLS pathway. A 90-kilodalton protein termed transportin was identified as a protein that specifically interacts with wild-type M9 but not transport-defective M9 mutants. Transportin and an ATP-regenerating system were found to be necessary and sufficient for import of M9-containing proteins in an in vitro import assay. In this report, we provide additional evidence that transportin can interact directly with M9-containing proteins and also show that it can mediate import of full-length hnRNP A1. In addition, Ran, or a Ran-binding protein, is identified as a second protein component of this novel nuclear import pathway. Transportin relatives from Saccharomyces cerevisiae which likely serve as additional nuclear transport receptors are described. | lld:pubmed |
| pubmed-article:8986607 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8986607 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8986607 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8986607 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8986607 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:8986607 | pubmed:author | pubmed-author:DreyfussGG | lld:pubmed |
| pubmed-article:8986607 | pubmed:author | pubmed-author:PollardVV | lld:pubmed |
| pubmed-article:8986607 | pubmed:author | pubmed-author:NakielnySS | lld:pubmed |
| pubmed-article:8986607 | pubmed:author | pubmed-author:MichaelW MWM | lld:pubmed |
| pubmed-article:8986607 | pubmed:author | pubmed-author:SiomiHH | lld:pubmed |
| pubmed-article:8986607 | pubmed:author | pubmed-author:SiomiM CMC | lld:pubmed |
| pubmed-article:8986607 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8986607 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8986607 | pubmed:volume | 229 | lld:pubmed |
| pubmed-article:8986607 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8986607 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8986607 | pubmed:pagination | 261-6 | lld:pubmed |
| pubmed-article:8986607 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:meshHeading | pubmed-meshheading:8986607-... | lld:pubmed |
| pubmed-article:8986607 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8986607 | pubmed:articleTitle | Transportin: nuclear transport receptor of a novel nuclear protein import pathway. | lld:pubmed |
| pubmed-article:8986607 | pubmed:affiliation | Howard Hughes Medical Institute, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, 19104-6148, USA. | lld:pubmed |
| pubmed-article:8986607 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8986607 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8986607 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8986607 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3842 | entrezgene:pubmed | pubmed-article:8986607 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8986607 | lld:pubmed |
