| pubmed-article:8985976 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0020930 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0597979 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0077182 | lld:lifeskim |
| pubmed-article:8985976 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:8985976 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8985976 | pubmed:dateCreated | 1997-2-26 | lld:pubmed |
| pubmed-article:8985976 | pubmed:abstractText | A new variation of the Reformatzy reaction with use of I2/zinc and chlorotrimethylsilane in THF and a shortened work-up is described allowing the synthesis of a wide variety of substituted beta-lactams 3 in fairly good yield. These lactams are silylated according to the Peterson reaction yielding by reactions with appropriate carbonyl compounds E/Z-mixturs of the substituted 3-methylidene beta-lactams 7, 8 and 10. The isomers are separated by CC and completely characterized by spectroscopic methods, mainly 1H NMR spectroscopy. Condensation of the 3-formyl methylidene derivative 10 with amines or malonate yields the conjugated products 11, and from the isopropylidene derivative 6 the pyridinium sulfonate 14 is prepared via 12 and 13. All methylidene beta-lactams are prepared as model compounds for studying their activity against beta-lactamases and for elucidating the mechanism of action. | lld:pubmed |
| pubmed-article:8985976 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8985976 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8985976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8985976 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8985976 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8985976 | pubmed:issn | 0031-7144 | lld:pubmed |
| pubmed-article:8985976 | pubmed:author | pubmed-author:JohnenAA | lld:pubmed |
| pubmed-article:8985976 | pubmed:author | pubmed-author:RueRR | lld:pubmed |
| pubmed-article:8985976 | pubmed:author | pubmed-author:OttoH HHH | lld:pubmed |
| pubmed-article:8985976 | pubmed:author | pubmed-author:GürtlerSS | lld:pubmed |
| pubmed-article:8985976 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8985976 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:8985976 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8985976 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8985976 | pubmed:pagination | 811-5 | lld:pubmed |
| pubmed-article:8985976 | pubmed:dateRevised | 2007-1-29 | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:meshHeading | pubmed-meshheading:8985976-... | lld:pubmed |
| pubmed-article:8985976 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8985976 | pubmed:articleTitle | 3-Methylidene-beta-lactams as potential inhibitors of beta-lactamases. Part 1: Synthesis of alpha-substituted derivatives from imines by Reformatzky reaction with chlorotrimethylsilane, silylation and Peterson olefination. | lld:pubmed |
| pubmed-article:8985976 | pubmed:affiliation | Institute of Pharmaceutical/Medicinal Chemistry, University of Greifswald, Germany. | lld:pubmed |
| pubmed-article:8985976 | pubmed:publicationType | Journal Article | lld:pubmed |
