Linked Life Data

8981262

Source:http://linkedlifedata.com/resource/pubmed/id/8981262

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pubmed-article:8981262pubmed:abstractTextMammalian pinealocytes are neuroendocrine cells that synthesize and secrete melatonin, these processes being positively controlled by norepinephrine derived from innervating sympathetic neurons. Previously, we showed that pinealocytes contain a large number of microvesicles (MVs) that specifically accumulate L-glutamate through a vesicular glutamate transporter and contain proteins for exocytosis such as synaptobrevin 2 (VAMP2). These findings suggested that the MVs are counterparts of synaptic vesicles and are involved in paracrine-like chemical transduction in the pineal gland. Here, we show that pinealocytes actually secrete glutamate upon stimulation by KCl in the presence of Ca2+ at 37 degrees C. The ability of glutamate secretion disappeared when the cells were incubated at below 20 degrees C. Loss of the activity was also observed on successive stimulation, but it was recovered after 12 hr incubation. A low concentration of cadmium chloride or omega-conotoxin GVIA inhibited the secretion. Botulinum neurotoxin E cleaved synaptic vesicle-associated protein 25 (SNAP-25) and thus inhibited the secretion. The released L-glutamate stimulated pinealocytes themselves via glutamate receptor(s) and inhibited norepinephrine-stimulated melatonin secretion. These results strongly suggest that pinealocytes are glutaminergic paraneurons, and that the glutaminergic system regulates negatively the synthesis and secretion of melatonin. The MV-mediated paracrine-like chemical transduction seems to be a novel mechanism that regulates hormonal secretion by neuroendocrine cells.lld:pubmed
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pubmed-article:8981262pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8981262pubmed:articleTitleMicrovesicle-mediated exocytosis of glutamate is a novel paracrine-like chemical transduction mechanism and inhibits melatonin secretion in rat pinealocytes.lld:pubmed
pubmed-article:8981262pubmed:affiliationDivision of Marine Molecular Biology, Graduate School of Gene Sciences, Hiroshima University, Japan.lld:pubmed
pubmed-article:8981262pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8981262pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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