| pubmed-article:8976196 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8976196 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:8976196 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8976196 | lifeskim:mentions | umls-concept:C0007745 | lld:lifeskim |
| pubmed-article:8976196 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:8976196 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:8976196 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8976196 | pubmed:dateCreated | 1997-1-30 | lld:pubmed |
| pubmed-article:8976196 | pubmed:abstractText | Ceramides are intramembrane diffusible mediators involved in transducing signals originated from a variety of cell surface receptors. Different adaptive and differentiative cellular responses, including apoptotic cell death, use ceramide-mediated pathways as an essential part of the program. Here, we show that human dendritic cells respond to CD40 ligand, as well as to tumor necrosis factor-alpha and IL-1 beta, with intracellular ceramide accumulation, as they are induced to differentiate. Dendritic cells down-modulate their capacity to take up soluble antigens in response to exogenously added or endogenously produced ceramides. This is followed by an impairment in presenting soluble antigens to specific T cell clones, while cell viability and the capacity to stimulate allogeneic responses or to present immunogenic peptides is fully preserved. Thus, ceramide-mediated pathways initiated by different cytokines can actively modulate professional antigen-presenting cell function and antigen-specific immune responses. | lld:pubmed |
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| pubmed-article:8976196 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8976196 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976196 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8976196 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8976196 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8976196 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8976196 | pubmed:author | pubmed-author:TestaJJ | lld:pubmed |
| pubmed-article:8976196 | pubmed:author | pubmed-author:De MariaRR | lld:pubmed |
| pubmed-article:8976196 | pubmed:author | pubmed-author:SallustoFF | lld:pubmed |
| pubmed-article:8976196 | pubmed:author | pubmed-author:CorintiSS | lld:pubmed |
| pubmed-article:8976196 | pubmed:author | pubmed-author:NicolòCC | lld:pubmed |
| pubmed-article:8976196 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8976196 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8976196 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:8976196 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8976196 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8976196 | pubmed:pagination | 2411-6 | lld:pubmed |
| pubmed-article:8976196 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8976196 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8976196 | pubmed:articleTitle | Ceramide inhibits antigen uptake and presentation by dendritic cells. | lld:pubmed |
| pubmed-article:8976196 | pubmed:affiliation | Department of Immunology, Istituto Superiore di Sanità, Rome, Italy. | lld:pubmed |
| pubmed-article:8976196 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8976196 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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