| pubmed-article:8976187 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0814999 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0022702 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:8976187 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:8976187 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8976187 | pubmed:dateCreated | 1997-1-30 | lld:pubmed |
| pubmed-article:8976187 | pubmed:abstractText | After productive rearrangement of a TCR beta chain gene, CD4-8- double negative (DN) thymocytes express TCR beta polypeptide chains on the cell surface together with pre-T alpha and the CD3 complex forming the pre-TCR. Signals transmitted through the pre-TCR select TCR beta + DN thymocytes for further maturation to the CD4+8+ double positive stage, whereas DN cells that fail to generate a productive TCR beta gene rearrangement do not continue in development. This process is termed TCR beta chain selection. Although it is likely that differences between proliferation dynamics of TCR beta + and TCR beta-cells may play a role, the exact mechanisms of TCR beta chain selection have not been elucidated. We therefore studied the proliferation dynamics of TCR beta + and TCR beta-thymocytes during fetal development, i.e., when TCR beta chain selection takes place for the first time. We analyzed in situ accumulation of TCR beta + thymocytes by confocal microscopy, and determined cell cycle and division parameters of TCR beta + and TCR beta-populations by flow cytometry. About 600 TCR beta + cells/thymic lobe are generated by independent induction events between days of gestation (dg) 13.5, and 15.5. As of dg 14.5, most TCR beta + cells have entered S/G2 phase of cell cycle, followed by seven to eight rapid cell divisions in fetal thymic organ culture, suggesting a corresponding burst of nine cell divisions within 4 d in vivo. By dg 18.5, the division rate of TCR beta + cells has slowed down to less than 1/d. About three quarters of TCR beta-cells divide at a slow rate of 1/d on dg 14.5, the proportion of nondividing cells increasing to 50% within the following four d. From dg 16.5 onwards, TCR beta-cells, but not TCR beta + cells, contain a significant proportion of apoptotic cells. The results suggest that failure to become selected results in shutdown of proliferation and eventual programmed cell death of fetal TCR beta-cells. Positive selection of fetal TCR beta + cells is achieved by an increased rate of cell divisions lasting for approximately 4 d. | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8976187 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8976187 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8976187 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8976187 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8976187 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8976187 | pubmed:author | pubmed-author:KohlerHH | lld:pubmed |
| pubmed-article:8976187 | pubmed:author | pubmed-author:EichmannKK | lld:pubmed |
| pubmed-article:8976187 | pubmed:author | pubmed-author:FalkII | lld:pubmed |
| pubmed-article:8976187 | pubmed:author | pubmed-author:BiroJJ | lld:pubmed |
| pubmed-article:8976187 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8976187 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8976187 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:8976187 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8976187 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8976187 | pubmed:pagination | 2327-39 | lld:pubmed |
| pubmed-article:8976187 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:meshHeading | pubmed-meshheading:8976187-... | lld:pubmed |
| pubmed-article:8976187 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8976187 | pubmed:articleTitle | Proliferation kinetics associated with T cell receptor-beta chain selection of fetal murine thymocytes. | lld:pubmed |
| pubmed-article:8976187 | pubmed:affiliation | Max-Planck-Institut für Immunbiologie, Freiburg, Germany. | lld:pubmed |
| pubmed-article:8976187 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8976187 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8976187 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8976187 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8976187 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8976187 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8976187 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8976187 | lld:pubmed |
