pubmed-article:8972221 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C0079183 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C0169665 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C0079184 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C1332737 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C1705523 | lld:lifeskim |
pubmed-article:8972221 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
pubmed-article:8972221 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:8972221 | pubmed:dateCreated | 1997-1-22 | lld:pubmed |
pubmed-article:8972221 | pubmed:abstractText | Cyclin E is necessary and rate limiting for the passage of mammalian cells through the G1 phase of the cell cycle. Control of cell cycle progression by cyclin E involves cdk2 kinase, which requires cyclin E for catalytic activity. Expression of cyclin E/cdk2 leads to an activation of cyclin A gene expression, as monitored by reporter gene constructs derived from the human cyclin A promoter. Promoter activation by cyclin E/cdk2 requires an E2F binding site in the cyclin A promoter. We show here that cyclin E/cdk2 kinase can directly bind to E2F/p107 complexes formed on the cyclin A promoter-derived E2F binding site, and this association is controlled by p27KIP1, most likely through direct protein-protein interaction. These observation suggest that cyclin E/cdk2 associates with E2F/p107 complexes in late G1 phase, once p27KIP1 has decreased below a critical threshold level. Since a kinase-negative mutant of cdk2 prevents promoter activation, it appears that transcriptional activation of the cyclin A gene requires an active cdk2 kinase tethered to its promoter region. | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:language | eng | lld:pubmed |
pubmed-article:8972221 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:8972221 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |