| pubmed-article:8972193 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8972193 | lifeskim:mentions | umls-concept:C0035366 | lld:lifeskim |
| pubmed-article:8972193 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:8972193 | lifeskim:mentions | umls-concept:C0699789 | lld:lifeskim |
| pubmed-article:8972193 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8972193 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:8972193 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8972193 | pubmed:dateCreated | 1997-1-22 | lld:pubmed |
| pubmed-article:8972193 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8972193 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8972193 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8972193 | pubmed:abstractText | A common feature of gene expression in all retroviruses is that unspliced, intron-containing RNA is exported to the cytoplasm despite the fact that cellular RNAs which contain introns are usually restricted to the nucleus. In complex retroviruses, the export of intron-containing RNA is mediated by specific viral regulatory proteins (e.g., human immunodeficiency virus type 1 [HIV-1] Rev) that bind to elements in the viral RNA. However, simpler retroviruses do not encode such regulatory proteins. Here we show that the genome of the simpler retrovirus Mason-Pfizer monkey virus (MPMV) contains an element that serves as an autonomous nuclear export signal for intron-containing RNA. This element is essential for MPMV replication; however, its function can be complemented by HIV-1 Rev and the Rev-responsive element. The element can also facilitate the export of cellular intron-containing RNA. These results suggest that the MPMV element mimics cellular RNA transport signals and mediates RNA export through interaction with endogenous cellular factors. | lld:pubmed |
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| pubmed-article:8972193 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8972193 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8972193 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8972193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8972193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8972193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8972193 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8972193 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8972193 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8972193 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8972193 | pubmed:author | pubmed-author:BrasGG | lld:pubmed |
| pubmed-article:8972193 | pubmed:author | pubmed-author:HammarskjöldM... | lld:pubmed |
| pubmed-article:8972193 | pubmed:author | pubmed-author:RekoshDD | lld:pubmed |
| pubmed-article:8972193 | pubmed:author | pubmed-author:ErnstR KRK | lld:pubmed |
| pubmed-article:8972193 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8972193 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:8972193 | pubmed:owner | NLM | lld:pubmed |
