| pubmed-article:8964597 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0040549 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0206527 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8964597 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8964597 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:8964597 | pubmed:dateCreated | 1996-12-17 | lld:pubmed |
| pubmed-article:8964597 | pubmed:abstractText | Several immune-mediated dermatoses including psoriasis and atopic dermatitis can be exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from skin lesions of these dermatoses. Consistent with superantigen effects, skewed T cell receptor variable gene usage has been demonstrated within these lesions. Therefore, the question arises whether superantigen induce a skin-seeking phenotype within peripheral T cells. In this study, we investigated the in vitro influence of the V beta 2-selective superantigen exfoliative toxin from Staphylococcus aureus on the expression of the cutaneous lymphocyte-associated antigen on peripheral T lymphocytes of healthy donors. We demonstrate that exfoliative toxin dramatically upregulates cutaneous lymphocyte-associated antigen expression on T cell receptor V beta 2+ lymphocytes. Up to 69% of V beta 2+ lymphocytes expressed cutaneous lymphocyte-associated antigen after 5 days of in vitro culture. Additionally, exfoliative toxin also increased cutaneous lymphocyte-associated antigen expression in CD3+ T cell receptor V beta 2- lymphocytes indicating a different effect as caused by the superantigen-T cell receptor V beta 2 interaction. Our findings suggest influence of bacterial superantigens on T lymphocyte skin homing in vivo. | lld:pubmed |
| pubmed-article:8964597 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8964597 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8964597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8964597 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8964597 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8964597 | pubmed:issn | 0165-2478 | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:KaufmannS HSH | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:KaufmannRR | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:MunkM EME | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:SterryWW | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:KellerTT | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:DuijvestijnA... | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:BoehnckeW HWH | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:ZollnerT MTM | lld:pubmed |
| pubmed-article:8964597 | pubmed:author | pubmed-author:NuberVV | lld:pubmed |
| pubmed-article:8964597 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8964597 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:8964597 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8964597 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8964597 | pubmed:pagination | 111-6 | lld:pubmed |
| pubmed-article:8964597 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:meshHeading | pubmed-meshheading:8964597-... | lld:pubmed |
| pubmed-article:8964597 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8964597 | pubmed:articleTitle | The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes. | lld:pubmed |
| pubmed-article:8964597 | pubmed:affiliation | Department of Dermatology, University of Frankfurt, Germany. | lld:pubmed |
| pubmed-article:8964597 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8964597 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8964597 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8964597 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8964597 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8964597 | lld:pubmed |
