| pubmed-article:8962098 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C0250416 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C0234621 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:8962098 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8962098 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:8962098 | pubmed:dateCreated | 1997-1-15 | lld:pubmed |
| pubmed-article:8962098 | pubmed:abstractText | Expression of G protein-regulated phospholipase C (PLC) beta 4 in the retina, lateral geniculate nucleus, and superior colliculus implies that PLC beta 4 may play a role in the mammalian visual process. A mouse line that lacks PLC beta 4 was generated and the physiological significance of PLC beta 4 in murine visual function was investigated. Behavioral tests using a shuttle box demonstrated that the mice lacking PLC beta 4 were impaired in their visual processing abilities, whereas they showed no deficit in their auditory abilities. In addition, the PLC beta 4-null mice showed 4-fold reduction in the maximal amplitude of the rod a- and b-wave components of their electroretinograms relative to their littermate controls. However, recording from single rod photoreceptors did not reveal any significant differences between the PLC beta 4-null and wild-type littermates, nor were there any apparent differences in retinas examined with light microscopy. While the behavioral and electroretinographic results indicate that PLC beta 4 plays a significant role in mammalian visual signal processing, isolated rod recording shows little or no apparent deficit, suggesting that the effect of PLC beta 4 deficiency on the rod signaling pathway occurs at some stage after the initial phototransduction cascade and may require cell-cell interactions between rods and other retinal cells. | lld:pubmed |
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| pubmed-article:8962098 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8962098 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8962098 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8962098 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8962098 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8962098 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:PughEE | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:WuDD | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:SimonM IMI | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:DoddRR | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:JiangHH | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:BaylorDD | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:VardiNN | lld:pubmed |
| pubmed-article:8962098 | pubmed:author | pubmed-author:LyubarskyAA | lld:pubmed |
| pubmed-article:8962098 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8962098 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:8962098 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8962098 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8962098 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8962098 | pubmed:pagination | 14598-601 | lld:pubmed |
| pubmed-article:8962098 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8962098 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8962098 | pubmed:articleTitle | Phospholipase C beta 4 is involved in modulating the visual response in mice. | lld:pubmed |
| pubmed-article:8962098 | pubmed:affiliation | Department of Pharmacology and Physiology, University of Rochester, NY 14642, USA. | lld:pubmed |
| pubmed-article:8962098 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8962098 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:18798 | entrezgene:pubmed | pubmed-article:8962098 | lld:entrezgene |
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