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pubmed-article:8958473pubmed:abstractTextSmear preparations were made from cells harvested from pleural fluid from 90 patients with breast cancer and stained for transferrin receptor (TRFr) and insulin-like growth factor-I receptor (IGF-Ir) using an immunocytochemical technique. The results were correlated with those from 36 benign effusions smears. In malignant smears from the breast cancer cases TRFr was demonstrated in 84.4% of the cellular deposits and IGF-Ir in 91.1%. TRFr was demonstrated in two (11%) of the tuberculous effusion smears and in six (100%) effusions from patients with collagen disease. IGF-Ir was not demonstrated in any of the smears from patients with benign disease. The sensitivity and specificity of TRFr staining were 84.4% and 77.7%, respectively, and for IGF-Ir staining were 91.1% and 100%, respectively. The underlying metabolic changes in the tumour cells which give rise to positive staining with these markers are discussed.lld:pubmed
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pubmed-article:8958473pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:8958473pubmed:articleTitleExpression of insulin-like growth factor-I receptor and transferrin receptor by breast cancer cells in pleural effusion smears.lld:pubmed
pubmed-article:8958473pubmed:affiliationDepartment of Pathology, Athens University Medical School, Greece.lld:pubmed
pubmed-article:8958473pubmed:publicationTypeJournal Articlelld:pubmed