| pubmed-article:8954915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C0009055 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C1412517 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C1423613 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C0596543 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C1157202 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C0178666 | lld:lifeskim |
| pubmed-article:8954915 | lifeskim:mentions | umls-concept:C1720675 | lld:lifeskim |
| pubmed-article:8954915 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8954915 | pubmed:dateCreated | 1997-1-22 | lld:pubmed |
| pubmed-article:8954915 | pubmed:abstractText | The signal transduction pathway by which insulin stimulates glucose transport is largely unknown, but a role of PI-3-kinase and small GTP-binding proteins has been proposed. In previous studies we, among many others, excluded a role for the ras/MAP kinase pathway in insulin-mediated glucose transport. In this study we examined a possible role of the small GTP-binding protein rho in this process. Pretreatment of 3T3-L1 adipocytes with botulinum C3 exoenzyme (C3), which is known to ADP-ribosylate and inactivate rho, potently stimulated glucose uptake to a level similar to insulin. Interestingly, glycogen synthesis was not affected by C3 treatment. Insulin stimulates glucose uptake by triggering the translocation of GLUT4, the insulin-sensitive glucose transporter isotype, from an intracellular compartment to the plasma membrane. Similarly, C3-induced glucose uptake was paralleled by GLUT4 translocation. These data point to an important and novel role of the target of C3 (likely rho) in the regulation of GLUT4-mediated glucose transport. Our data suggest that insulin might stimulate glucose uptake through inactivation of rho. | lld:pubmed |
| pubmed-article:8954915 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8954915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8954915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8954915 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8954915 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:8954915 | pubmed:author | pubmed-author:KransH MHM | lld:pubmed |
| pubmed-article:8954915 | pubmed:author | pubmed-author:van den... | lld:pubmed |
| pubmed-article:8954915 | pubmed:author | pubmed-author:BarrosL FLF | lld:pubmed |
| pubmed-article:8954915 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:8954915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8954915 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:8954915 | pubmed:volume | 229 | lld:pubmed |
| pubmed-article:8954915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8954915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8954915 | pubmed:pagination | 430-9 | lld:pubmed |
| pubmed-article:8954915 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
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| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
| pubmed-article:8954915 | pubmed:meshHeading | pubmed-meshheading:8954915-... | lld:pubmed |
| pubmed-article:8954915 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8954915 | pubmed:articleTitle | Clostridium botulinum C3 exoenzyme stimulates GLUT4-mediated glucose transport, but not glycogen synthesis, in 3T3-L1 adipocytes--a potential role of rho? | lld:pubmed |
| pubmed-article:8954915 | pubmed:affiliation | Department of Endocrinology, University Hospital Leiden, The Netherlands. van-den-berghe@mpi-dortmund.mpg.de | lld:pubmed |
| pubmed-article:8954915 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8954915 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8954915 | lld:pubmed |
