| pubmed-article:8953188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8953188 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:8953188 | lifeskim:mentions | umls-concept:C0302908 | lld:lifeskim |
| pubmed-article:8953188 | lifeskim:mentions | umls-concept:C0066005 | lld:lifeskim |
| pubmed-article:8953188 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:8953188 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8953188 | pubmed:dateCreated | 1997-3-18 | lld:pubmed |
| pubmed-article:8953188 | pubmed:abstractText | High-performance liquid chromatographic procedures have been developed for the measurement of meropenem in serum. The separation was performed on an Ultrasphere XL-ODS analytical column (75 x 4.6 min I.D.). The mobile phase consisted of 10.53 mmol/l ammonium acetate-acetonitrile (95:5, v/v) (pH 4). The UV detection was at 298 nm. The quantitation limit both in serum and water was 0.25 micrograms/ml. The method was validated in serum and aqueous solution over the concentration range 0.25-50 micrograms/ml. The extraction recovery from serum spiked with meropenem was 99.7 +/- 3.4%. The intra- and inter-assay coefficients of variation were below 6%. Stored at -80 degrees C for three months at various concentrations in serum and in aqueous solution, meropenem did not reveal any appreciable degradation. After 24 h, it was also stable at 4 degrees C in serum, aqueous solution and supernatant of extraction but not at room temperature. The stability of the drug was also confirmed in serum after repeated freezing-thawing cycles at -80 degrees C on four consecutive days. | lld:pubmed |
| pubmed-article:8953188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8953188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8953188 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8953188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8953188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8953188 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8953188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8953188 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8953188 | pubmed:issn | 1572-6495 | lld:pubmed |
| pubmed-article:8953188 | pubmed:author | pubmed-author:LevequeDD | lld:pubmed |
| pubmed-article:8953188 | pubmed:author | pubmed-author:JehlFF | lld:pubmed |
| pubmed-article:8953188 | pubmed:author | pubmed-author:LingerLL | lld:pubmed |
| pubmed-article:8953188 | pubmed:author | pubmed-author:PomperMM | lld:pubmed |
| pubmed-article:8953188 | pubmed:author | pubmed-author:ElkhaïliHH | lld:pubmed |
| pubmed-article:8953188 | pubmed:author | pubmed-author:NiedergangSS | lld:pubmed |
| pubmed-article:8953188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8953188 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:8953188 | pubmed:volume | 686 | lld:pubmed |
| pubmed-article:8953188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8953188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8953188 | pubmed:pagination | 19-26 | lld:pubmed |
| pubmed-article:8953188 | pubmed:dateRevised | 2007-10-16 | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:meshHeading | pubmed-meshheading:8953188-... | lld:pubmed |
| pubmed-article:8953188 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8953188 | pubmed:articleTitle | High-performance liquid chromatographic assay for meropenem in serum. | lld:pubmed |
| pubmed-article:8953188 | pubmed:affiliation | Laboratory of Pharmacokinetics, University Hospital Center, Strasbourg, France. | lld:pubmed |
| pubmed-article:8953188 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8953188 | pubmed:publicationType | Comparative Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8953188 | lld:pubmed |
