| pubmed-article:8952531 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8952531 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:8952531 | lifeskim:mentions | umls-concept:C0064294 | lld:lifeskim |
| pubmed-article:8952531 | lifeskim:mentions | umls-concept:C0026565 | lld:lifeskim |
| pubmed-article:8952531 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8952531 | pubmed:dateCreated | 1997-1-14 | lld:pubmed |
| pubmed-article:8952531 | pubmed:abstractText | Keratinocyte growth factor (KGF) is a growth factor for type II pneumocytes. Type II pneumocyte hyperplasia, a common reaction to lung injury, has been postulated to play an important role in lung repair. The potential protective effect of KGF was therefore studied in rat models of radiation- and bleomycin-induced lung injury. Intratracheal instillation of KGF (5 mg/kg) 72 and 48 hours before 18 Gy of bilateral thoracic irradiation did not significantly improve survival, although histology showed less pneumonitis and fibrosis in KGF-pretreated as compared with control-irradiated rats. Intratracheal pretreatment with KGF in rats receiving intratracheal bleomycin (2.5 U) improved survival at 3 weeks to 100% (20/20 rats) from 40% (8/20 rats) in controls. All KGF-pretreated rats receiving bleomycin were well at 3 weeks and without histological evidence of pulmonary fibrosis whereas the 8 surviving control rats exhibited severe respiratory distress. Finally, in the most lethal challenge to the lung, rats pretreated with intratracheal KGF or saline were challenged with a combination of bleomycin (1.5 U) and bilateral thoracic irradiation (18 Gy). KGF-pretreated rats did not begin to die or show signs of respiratory distress until 7 weeks, whereas all saline-pretreated control rats receiving radiation and bleomycin died within approximately 4 weeks with severe respiratory distress and weight loss. In conclusion, radiation- and bleomycin-induced pulmonary injury and respiratory death are ameliorated by KGF pretreatment, suggesting a protective role for KGF-induced type II pneumocyte proliferation in lung injury. | lld:pubmed |
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| pubmed-article:8952531 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8952531 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8952531 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8952531 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8952531 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:WilliamsS TST | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:LeeHH | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:YinSS | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:UlichT RTR | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:DhoCC | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:CosoO AOA | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:TarpleyJJ | lld:pubmed |
| pubmed-article:8952531 | pubmed:author | pubmed-author:MalickiD MDM | lld:pubmed |
| pubmed-article:8952531 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8952531 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:8952531 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8952531 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8952531 | pubmed:pagination | 1963-70 | lld:pubmed |
| pubmed-article:8952531 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8952531 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8952531 | pubmed:articleTitle | Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. | lld:pubmed |
| pubmed-article:8952531 | pubmed:affiliation | Department of Pathology, School of Medicine, University of California at San Diego, USA. | lld:pubmed |
| pubmed-article:8952531 | pubmed:publicationType | Journal Article | lld:pubmed |
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