| pubmed-article:8951017 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8951017 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:8951017 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:8951017 | lifeskim:mentions | umls-concept:C0021815 | lld:lifeskim |
| pubmed-article:8951017 | lifeskim:mentions | umls-concept:C0011164 | lld:lifeskim |
| pubmed-article:8951017 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8951017 | lifeskim:mentions | umls-concept:C0037775 | lld:lifeskim |
| pubmed-article:8951017 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8951017 | pubmed:dateCreated | 1997-1-15 | lld:pubmed |
| pubmed-article:8951017 | pubmed:abstractText | We investigated the distribution of compressive 'stress' within cadaver intervertebral discs, using a pressure transducer mounted in a 1.3 mm diameter needle. The needle was pulled along the midsagittal diameter of a lumbar disc with the face of the transducer either vertical or horizontal while the disc was subjected to a constant compressive force. The resulting 'stress profiles' were analysed in order to characterise the distribution of vertical and horizontal compressive stress within each disc. A total of 87 discs from subjects aged between 16 and 87 years was examined. Our results showed that age-related degenerative changes reduced the diameter of the central hydrostatic region of each disc (the 'functional nucleus') by approximately 50%, and the pressure within this region fell by 30%. The width of the functional annulus increased by 80% and the height of compressive 'stress peaks' within it by 160%. The effects of age and degeneration were greater at L4/L5 than at L2/L3, and the posterior annulus was affected more than the anterior. Age and degeneration were themselves closely related, but the stage of degeneration had the greater effect on stress distributions. We suggest that structural changes within the annulus and endplate lead to a transfer of load from the nucleus to the posterior annulus. High 'stress' concentrations within the annulus may cause pain, and lead to further disruption. | lld:pubmed |
| pubmed-article:8951017 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8951017 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8951017 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8951017 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8951017 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8951017 | pubmed:issn | 0301-620X | lld:pubmed |
| pubmed-article:8951017 | pubmed:author | pubmed-author:DolanPP | lld:pubmed |
| pubmed-article:8951017 | pubmed:author | pubmed-author:AdamsM AMA | lld:pubmed |
| pubmed-article:8951017 | pubmed:author | pubmed-author:McNallyD SDS | lld:pubmed |
| pubmed-article:8951017 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8951017 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:8951017 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8951017 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8951017 | pubmed:pagination | 965-72 | lld:pubmed |
| pubmed-article:8951017 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:8951017 | pubmed:meshHeading | pubmed-meshheading:8951017-... | lld:pubmed |
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| pubmed-article:8951017 | pubmed:meshHeading | pubmed-meshheading:8951017-... | lld:pubmed |
| pubmed-article:8951017 | pubmed:meshHeading | pubmed-meshheading:8951017-... | lld:pubmed |
| pubmed-article:8951017 | pubmed:meshHeading | pubmed-meshheading:8951017-... | lld:pubmed |
| pubmed-article:8951017 | pubmed:meshHeading | pubmed-meshheading:8951017-... | lld:pubmed |
| pubmed-article:8951017 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8951017 | pubmed:articleTitle | 'Stress' distributions inside intervertebral discs. The effects of age and degeneration. | lld:pubmed |
| pubmed-article:8951017 | pubmed:affiliation | Department of Anatomy, University of Bristol, UK. | lld:pubmed |
| pubmed-article:8951017 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8951017 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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