| pubmed-article:8950992 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C0295022 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C1420888 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C1427812 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C1334346 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:8950992 | lifeskim:mentions | umls-concept:C1176299 | lld:lifeskim |
| pubmed-article:8950992 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8950992 | pubmed:dateCreated | 1997-1-9 | lld:pubmed |
| pubmed-article:8950992 | pubmed:abstractText | CD40, a member of the tumour necrosis factor receptor family, is expressed on the surface of B lymphocytes where its ligation provides a potent survival signal. CD40 is also expressed in basal epithelial cells and in a number of different carcinomas where its function remains unknown. We observed that contrary to the studies in normal B cells, CD40 ligation in carcinoma cell lines and in normal primary epithelial cells resulted in growth inhibition and enhanced susceptibility to apoptosis induced by anti-neoplastic drugs, TNF-alpha, Fas and ceramide. This effect was also observed in CD40-transfected Rat-1 fibroblasts. The expression of Bcl-2 did not affect growth inhibition induced by CD40 ligation in epithelial cells but the Epstein - Barr Virus-encoded latent membrane protein 1 (LMP1) blocked the effect. Whilst transient expression of LMP-1 resulted in the inhibition of epithelial cell growth, this effect was not observed with a LMP1 mutant lacking the binding domain for TRAF3, a protein which may mediate signal transduction by interacting with the cytoplasmic domains of both CD40 and LMP1. Transient expression of TRAF3 also inhibited epithelial cell growth, whilst expression of a dominant-negative TRAF3 partially blocked the inhibitory effect of CD40 ligation and of transient LMP1 expression. These results suggest that CD40 regulates epithelial cell growth in a manner mimicked by LMP1 and implicate TRAF3 as a common mediator in the transduction of the growth inhibitory signals generated via the CD40 and LMP1 pathways. | lld:pubmed |
| pubmed-article:8950992 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8950992 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8950992 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8950992 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8950992 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8950992 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8950992 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8950992 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:YoungL SLS | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:ReedJ CJC | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:DawsonJJ | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:KieffEE | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:RoweMM | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:WakelamM JMJ | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:ArmitageR JRJ | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:EliopoulosA... | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:DawsonC WCW | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:KerrD JDJ | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:ZapataJ MJM | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:MosialosGG | lld:pubmed |
| pubmed-article:8950992 | pubmed:author | pubmed-author:FloettmannJ... | lld:pubmed |
| pubmed-article:8950992 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8950992 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:8950992 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:8950992 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8950992 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8950992 | pubmed:pagination | 2243-54 | lld:pubmed |
| pubmed-article:8950992 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8950992 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8950992 | pubmed:articleTitle | CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. | lld:pubmed |
| pubmed-article:8950992 | pubmed:affiliation | CRC Institute for Cancer Studies, The University of Birmingham Medical School, UK. | lld:pubmed |
| pubmed-article:8950992 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8950992 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8950992 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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