| pubmed-article:8945471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8945471 | lifeskim:mentions | umls-concept:C0342276 | lld:lifeskim |
| pubmed-article:8945471 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:8945471 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:8945471 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8945471 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:8945471 | pubmed:issue | 6608 | lld:pubmed |
| pubmed-article:8945471 | pubmed:dateCreated | 1997-1-6 | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:abstractText | The disease maturity-onset diabetes of the young (MODY) is a genetically heterogeneous monogenic form of non-insulin-dependent (type 2) diabetes mellitus (NIDDM), characterized by early onset, usually before 25 years of age and often in adolescence or childhood, and by autosomal dominant inheritance. It has been estimated that 2-5% of patients with NIDDM may have this form of diabetes mellitus. Clinical studies have shown that prediabetic MODY subjects have normal insulin sensitivity but suffer from a defect in glucose-stimulated insulin secretion, suggesting that pancreatic beta-cell dysfunction rather than insulin resistance is the primary defect in this disorder. Linkage studies have localized the genes that are mutated in MODY on human chromosomes 20 (MODY1), 7 (MODY2) and 12 (MODY3), with MODY2 and MODY3 being allelic with the genes encoding glucokinase, a key regulator of insulin secretion, and hepatocyte nuclear factor-1alpha (HNF-1alpha), a transcription factor involved in tissue-specific regulation of liver genes but also expressed in pancreatic islets, insulinoma cells and other tissues. Here we show that MODY1 is the gene encoding HNF-4alpha (gene symbol, TCF14), a member of the steroid/thyroid hormone receptor superfamily and an upstream regulator of HNF-1alpha expression. | lld:pubmed |
| pubmed-article:8945471 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8945471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8945471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8945471 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8945471 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:FajansS SSS | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:COLEL JLJ | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:MenzelSS | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:FuruseSS | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:ROT KTK | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:YamagataKK | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:CoxN JNJ | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:StofferCC | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:KaisakiP JPJ | lld:pubmed |
| pubmed-article:8945471 | pubmed:author | pubmed-author:SignoriniSS | lld:pubmed |
| pubmed-article:8945471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8945471 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:8945471 | pubmed:volume | 384 | lld:pubmed |
| pubmed-article:8945471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8945471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8945471 | pubmed:pagination | 458-60 | lld:pubmed |
| pubmed-article:8945471 | pubmed:dateRevised | 2008-9-11 | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:meshHeading | pubmed-meshheading:8945471-... | lld:pubmed |
| pubmed-article:8945471 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8945471 | pubmed:articleTitle | Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) | lld:pubmed |
| pubmed-article:8945471 | pubmed:affiliation | Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA. | lld:pubmed |
| pubmed-article:8945471 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8945471 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8945471 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3172 | entrezgene:pubmed | pubmed-article:8945471 | lld:entrezgene |
| entrez-gene:15378 | entrezgene:pubmed | pubmed-article:8945471 | lld:entrezgene |
| entrez-gene:25735 | entrezgene:pubmed | pubmed-article:8945471 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8945471 | lld:pubmed |
