| pubmed-article:8943328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C0166033 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C1705630 | lld:lifeskim |
| pubmed-article:8943328 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:8943328 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8943328 | pubmed:dateCreated | 1997-1-31 | lld:pubmed |
| pubmed-article:8943328 | pubmed:abstractText | Optimal activation of T cells requires at least two signals delivered by the T-cell receptor complex and costimulatory molecules such as CD28. The CD28 signaling participates in the transcription of the interleukin-2 gene through activation of an enhancer termed the CD28-responsive element (CD28RE). Stimulation of CD28 enhances mitogen-mediated induction of CD28RE-binding proteins including members of the NF-kappaB/Rel transcription factor family, although the underlying mechanism remains elusive. In this report, we show that CD28 costimulation leads to biphasic induction of NF-kappaB/Rel heterodimers, including early-phase induction of p50/RelA and c-Rel/RelA and late-phase induction of p50/c-Rel. Interestingly, activation of these NF-kappaB/Rel complexes by the CD28 signal is associated with the rapid degradation of both IkappaBalpha and IkappaBbeta, two major cytoplasmic inhibitors of NF-kappaB/Rel. Although IkappaBalpha degradation can be induced by phorbol ester alone, degradation of IkappaBbeta is largely dependent on the CD28 costimulatory signal. We further demonstrate that CD28-mediated transactivation of the CD28RE enhancer is potently inhibited by an N-terminal truncation mutant of IkappaBbeta that is incapable of responding to the degradation signals. Together, these results suggest that the CD28 costimulatory signal augments activation of NF-kappaB/Rel by promoting degradation of IkappaBbeta as well as enhancing degradation of IkappaBalpha and that induction of NF-kappaB/Rel serves as an essential step in the signal-mediated activation of the CD28RE enhancer. | lld:pubmed |
| pubmed-article:8943328 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8943328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8943328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8943328 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8943328 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:8943328 | pubmed:author | pubmed-author:SunS CSC | lld:pubmed |
| pubmed-article:8943328 | pubmed:author | pubmed-author:GoodLL | lld:pubmed |
| pubmed-article:8943328 | pubmed:author | pubmed-author:MaggirwarS... | lld:pubmed |
| pubmed-article:8943328 | pubmed:author | pubmed-author:HarhajE WEW | lld:pubmed |
| pubmed-article:8943328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8943328 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:8943328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8943328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8943328 | pubmed:pagination | 6736-43 | lld:pubmed |
| pubmed-article:8943328 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:meshHeading | pubmed-meshheading:8943328-... | lld:pubmed |
| pubmed-article:8943328 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8943328 | pubmed:articleTitle | CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers. | lld:pubmed |
| pubmed-article:8943328 | pubmed:affiliation | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey 17033, USA. | lld:pubmed |
| pubmed-article:8943328 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8943328 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8943328 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8943328 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8943328 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8943328 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8943328 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8943328 | lld:pubmed |
