| pubmed-article:8943054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8943054 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:8943054 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8943054 | lifeskim:mentions | umls-concept:C0022567 | lld:lifeskim |
| pubmed-article:8943054 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:8943054 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:8943054 | lifeskim:mentions | umls-concept:C0332183 | lld:lifeskim |
| pubmed-article:8943054 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:8943054 | pubmed:dateCreated | 1997-1-16 | lld:pubmed |
| pubmed-article:8943054 | pubmed:abstractText | The multiple genetic hit model of cancer predicts that normal individuals should have stable populations of cancer-prone, but noncancerous, mutant cells awaiting further genetic hits. We report that whole-mount preparations of human skin contain clonal patches of p53-mutated keratinocytes, arising from the dermal-epidermal junction and from hair follicles. These clones, 60-3000 cells in size, are present at frequencies exceeding 40 cells per cm2 and together involve as much as 4% of the epidermis. In sun-exposed skin, clones are both more frequent and larger than in sun-shielded skin. We conclude that, in addition to being a tumorigenic mutagen, sunlight acts as a tumor promoter by favoring the clonal expansion of p53-mutated cells. These combined actions of sunlight result in normal individuals carrying a substantial burden of keratinocytes predisposed to cancer. | lld:pubmed |
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| pubmed-article:8943054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8943054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8943054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8943054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8943054 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8943054 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:PriceG JGJ | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:TaroneR ERE | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:BrashD EDE | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:PersingJ AJA | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:LeffellD JDJ | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:KunalaSS | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:SpinelliH MHM | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:RestifoR JRJ | lld:pubmed |
| pubmed-article:8943054 | pubmed:author | pubmed-author:JonasonA SAS | lld:pubmed |
| pubmed-article:8943054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8943054 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:8943054 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8943054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8943054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8943054 | pubmed:pagination | 14025-9 | lld:pubmed |
| pubmed-article:8943054 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8943054 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8943054 | pubmed:articleTitle | Frequent clones of p53-mutated keratinocytes in normal human skin. | lld:pubmed |
| pubmed-article:8943054 | pubmed:affiliation | Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA. | lld:pubmed |
| pubmed-article:8943054 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8943054 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8943054 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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