| pubmed-article:8942979 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8942979 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:8942979 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:8942979 | lifeskim:mentions | umls-concept:C0376571 | lld:lifeskim |
| pubmed-article:8942979 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:8942979 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:8942979 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:8942979 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:8942979 | pubmed:dateCreated | 1997-1-16 | lld:pubmed |
| pubmed-article:8942979 | pubmed:abstractText | Mutations in BRCA1 account for 45% of families with high incidence of breast cancer and for 80-90% of families with both breast and ovarian cancer. BRCA1 protein includes an amino-terminal zinc finger motif as well as an excess of negatively charged amino acids near the C terminus. In addition, BRCA1 contains two nuclear localization signals and localizes to the nucleus of normal cells. While these features suggest a role in transcriptional regulation, no function has been assigned to BRCA1. Here, we show that the C-terminal region, comprising exons 16-24 (aa 1560-1863) of BRCA1 fused to GAL4 DNA binding domain can activate transcription both in yeast and mammalian cells. Furthermore, we define the region comprising exons 21-24 (aa 1760-1863) as the minimal transactivation domain. Any one of four germ-line mutations in the C-terminal region found in patients with breast or ovarian cancer (Ala-1708-->Glu, Gln-1756 C+, Met-1775-->Arg, Tyr-1853 ->Stop), had markedly impaired transcription activity. Together these data underscore the notion that one of the functions of BRCA1 may be the regulation of transcription. | lld:pubmed |
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| pubmed-article:8942979 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8942979 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8942979 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8942979 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8942979 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8942979 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8942979 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8942979 | pubmed:author | pubmed-author:HanafusaHH | lld:pubmed |
| pubmed-article:8942979 | pubmed:author | pubmed-author:AugustAA | lld:pubmed |
| pubmed-article:8942979 | pubmed:author | pubmed-author:MonteiroA NAN | lld:pubmed |
| pubmed-article:8942979 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8942979 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:8942979 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8942979 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8942979 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8942979 | pubmed:pagination | 13595-9 | lld:pubmed |
| pubmed-article:8942979 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:8942979 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8942979 | pubmed:articleTitle | Evidence for a transcriptional activation function of BRCA1 C-terminal region. | lld:pubmed |
| pubmed-article:8942979 | pubmed:affiliation | Laboratory of Molecular Oncology, Rockfeller University, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:8942979 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8942979 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
