| pubmed-article:8938136 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C0241888 | lld:lifeskim |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C1704807 | lld:lifeskim |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C0920269 | lld:lifeskim |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C1155661 | lld:lifeskim |
| pubmed-article:8938136 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8938136 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8938136 | pubmed:dateCreated | 1997-1-2 | lld:pubmed |
| pubmed-article:8938136 | pubmed:abstractText | We examined 30 gastric-cancer patients with a varying degree of family history of stomach cancer and/or synchronous gastric tumors for microsatellite instability. We observed microsatellite instability at at least 1 of 8 loci tested in tumors of 14/30 patients; of these 14, 8 had single locus alterations and 6 had alterations at at least half of the 8 loci. Among the patients with microsatellite instability at > or = 4 loci, 3 patients showed a strong familial clustering of gastric cancer. Mutation analysis of the DNA mismatch repair gene hMLHl on paired non-tumorous and tumor DNA from 10 patients, 6 with microsatellite instability at > or = 4 loci and 4 with an alteration at one locus, revealed a novel missense mutation, present in the normal and tumor DNA of one patient with microsatellite instability at multiple loci in his tumor. His family history of cancer included one second-degree relative affected with gastric cancer. These data suggest that germline mutations in the hMLHl gene occur in some gastric-cancer patients and that in the majority of cases microsatellite instability in gastric tumors may be due to defects in other genes responsible for DNA replication fidelity than the hMLHl. | lld:pubmed |
| pubmed-article:8938136 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8938136 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8938136 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8938136 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8938136 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8938136 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:8938136 | pubmed:author | pubmed-author:GrimmVV | lld:pubmed |
| pubmed-article:8938136 | pubmed:author | pubmed-author:KellerGG | lld:pubmed |
| pubmed-article:8938136 | pubmed:author | pubmed-author:VogelsangHH | lld:pubmed |
| pubmed-article:8938136 | pubmed:author | pubmed-author:MuellerJJ | lld:pubmed |
| pubmed-article:8938136 | pubmed:author | pubmed-author:SiewertJ RJR | lld:pubmed |
| pubmed-article:8938136 | pubmed:author | pubmed-author:HöflerHH | lld:pubmed |
| pubmed-article:8938136 | pubmed:author | pubmed-author:BischoffPP | lld:pubmed |
| pubmed-article:8938136 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8938136 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:8938136 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:8938136 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8938136 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8938136 | pubmed:pagination | 571-6 | lld:pubmed |
| pubmed-article:8938136 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8938136 | pubmed:meshHeading | pubmed-meshheading:8938136-... | lld:pubmed |
| pubmed-article:8938136 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8938136 | pubmed:articleTitle | Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer. | lld:pubmed |
| pubmed-article:8938136 | pubmed:affiliation | Department of Pathology, Technical University Munich, Germany. | lld:pubmed |
| pubmed-article:8938136 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8938136 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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