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pubmed-article:8934617pubmed:abstractText1. Recent studies have provided insight into how the expression of endothelial cell nitric oxide synthase (ecNOS) is regulated. 2. The promoter of ecNOS has several features that are compatible with a constitutively expressed, so-called 'house keeping' gene. These include absence of a TATA box and the presence of Sp1 binding sites located near the transcription start site. The promoter also contains a number of putative binding domains which suggests that it may be regulated by a variety of transcription factor mediated signals. 3. Studies of cultured endothelial cells suggest that ecNOS expression is modulated by shear stress, transforming growth factor beta, inhibition of protein kinase C and the state of proliferation. These experiments indicate that although the ecNOS is a 'constitutively expressed' gene, its content in the endothelium is subject to modest degrees of regulation that may have important physiological and pathophysiological implications.lld:pubmed
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pubmed-article:8934617pubmed:articleTitleRegulation of expression of the endothelial cell nitric oxide synthase.lld:pubmed
pubmed-article:8934617pubmed:affiliationDepartment of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.lld:pubmed
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