| pubmed-article:8927498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0017070 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0054450 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0178702 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8927498 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:8927498 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8927498 | pubmed:dateCreated | 1996-11-6 | lld:pubmed |
| pubmed-article:8927498 | pubmed:abstractText | Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If capsaicin is applied continuously or repeatedly then there is a progressive decline in responsiveness. We have studied the mechanism of this desensitization using electrophysiological methods in cultured dorsal root ganglion neurones from adult rats. The rate of desensitization of capsaicin-induced responses is partly dependent on the extracellular calcium concentration and is slower when extracellular calcium is reduced. Desensitization is strongly inhibited by intracellular application of the calcium chelator 1,2-bis(2-aminophenoxy)ethane-N, N, N',N'-tetraacetic acid (BAPTA). These data suggest that desensitization is due to a rapid rise in intracellular calcium levels which occurs when capsaicin-sensitive ion channels are activated. Desensitization is not reduced by the non-specific protein kinase inhibitors H7 or staurosporine or by okadaic acid, a selective inhibitor of protein phosphatases 1 and 2A. Desensitization is greatly reduced by cyclosporin A complexed to cyclophilin, which is a specific inhibitor of protein phoshatase 2B (calcineurin). A mechanism for desensitization of capsaicin responsiveness is proposed whereby the evoked rise in calcium activates calcineurin leading to dephosphorylation and desensitization of the capsaicin-sensitive ion channels. | lld:pubmed |
| pubmed-article:8927498 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8927498 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8927498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8927498 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8927498 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:8927498 | pubmed:author | pubmed-author:BevanSS | lld:pubmed |
| pubmed-article:8927498 | pubmed:author | pubmed-author:DochertyR JRJ | lld:pubmed |
| pubmed-article:8927498 | pubmed:author | pubmed-author:BoddekeH WHW | lld:pubmed |
| pubmed-article:8927498 | pubmed:author | pubmed-author:YeatsJ CJC | lld:pubmed |
| pubmed-article:8927498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8927498 | pubmed:volume | 431 | lld:pubmed |
| pubmed-article:8927498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8927498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8927498 | pubmed:pagination | 828-37 | lld:pubmed |
| pubmed-article:8927498 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:8927498 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8927498 | pubmed:articleTitle | Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats. | lld:pubmed |
| pubmed-article:8927498 | pubmed:affiliation | Sandoz Institute for Medical Research, 5 Gower Pl, London WC1E 6BN, UK. | lld:pubmed |
| pubmed-article:8927498 | pubmed:publicationType | Journal Article | lld:pubmed |
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