| pubmed-article:8921285 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C1518683 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C0009195 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8921285 | lifeskim:mentions | umls-concept:C0599668 | lld:lifeskim |
| pubmed-article:8921285 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8921285 | pubmed:dateCreated | 1997-1-2 | lld:pubmed |
| pubmed-article:8921285 | pubmed:abstractText | Acetylcholine-evoked currents were investigated using the conventional whole-cell patch-clamp recording technique in developing outer hair cells (OHCs). The cells were isolated from the rat cochlea at different stages of postnatal development ranging from day 4 (P4) to P30. Acetylcholine-evoked currents could be recorded at P6 and P8. At this developmental stage, the majority of OHCs displayed inward nicotinic-like currents near the resting membrane potential. These cholinergic currents zeroed near 0 mV, as expected for a non-selective cation current, and could be reversibly blocked by d-tubocurarine. At P12 and adult stage, the cholinergic response of OHCs switched to an outward current reversing near EK and displaying a bell shape peaking between -40 and -30 mV. This change in polarity of the acetylcholine response during postnatal development might be explained by progressive functional coupling between acetylcholine ionotropic receptors permeable to Ca2+ and nearby Ca(2+)-activated K+ channels at the synaptic pole of OHCs. | lld:pubmed |
| pubmed-article:8921285 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8921285 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8921285 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8921285 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8921285 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8921285 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8921285 | pubmed:issn | 0953-816X | lld:pubmed |
| pubmed-article:8921285 | pubmed:author | pubmed-author:LenoirMM | lld:pubmed |
| pubmed-article:8921285 | pubmed:author | pubmed-author:DulonDD | lld:pubmed |
| pubmed-article:8921285 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8921285 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:8921285 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8921285 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8921285 | pubmed:pagination | 1945-52 | lld:pubmed |
| pubmed-article:8921285 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:meshHeading | pubmed-meshheading:8921285-... | lld:pubmed |
| pubmed-article:8921285 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8921285 | pubmed:articleTitle | Cholinergic responses in developing outer hair cells of the rat cochlea. | lld:pubmed |
| pubmed-article:8921285 | pubmed:affiliation | Laboratoire d'Audiologie Expérimentale, INSERM et Université de Bordeaux II, Hôpital Pellegrin, France. | lld:pubmed |
| pubmed-article:8921285 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8921285 | pubmed:publicationType | In Vitro | lld:pubmed |
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