| pubmed-article:8920995 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8920995 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
| pubmed-article:8920995 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:8920995 | lifeskim:mentions | umls-concept:C0025255 | lld:lifeskim |
| pubmed-article:8920995 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:8920995 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:8920995 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:8920995 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8920995 | pubmed:dateCreated | 1996-12-30 | lld:pubmed |
| pubmed-article:8920995 | pubmed:abstractText | The Triton-insoluble complex from porcine lung membranes has been separated into two distinct subfractions visible as discrete light-scattering bands following buoyant density-gradient centrifugation in sucrose. Both of these detergent-insoluble complexes were enriched in the glycosyl-phosphatidylinositol (GPI)-anchored ectoenzymes alkaline phosphatase, aminopeptidase P and 5'-nucleotidase, and both complexes excluded the polypeptide-anchored ectoenzymes angiotensin-converting enzyme, dipeptidyl peptidase IV and aminopeptidases A and N. The GPI-anchored proteins in both complexes were susceptible to release by phosphatidylinositol-specific phospholipase C. Both complexes were also enriched in cholesterol and glycosphingolipids, and in caveolin/VIP21, although only the higher-density fraction was enriched in the plasmalemmal caveolar marker proteins Ca(2+)-ATPase and the inositol 1,4,5-trisphosphate receptor. Among the annexin family of proteins, annexins I and IV were absent from the two detergent-insoluble complexes, annexin V was present in both, and annexins II and VI were only enriched in the higher-density fraction. When the mental chelator EGTA was present in the isolation buffers, annexins II and VI dissociated from the higher-density detergent-insoluble complex and only a single light-scattering band was observed on the sucrose gradient, at the same position as for the lower-density complex. In contrast, in the presence of excess calcium only a single detergent-insoluble complex was isolated from the sucrose gradients, at an intermediate density. Thus the detergent-insoluble membrane complex can be subfractionated on the basis of what appears to be calcium-dependent, annexin-mediated, vesicle aggregation into two distinct populations, only one of which is enriched in plasmalemmal caveolar marker proteins. | lld:pubmed |
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| pubmed-article:8920995 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8920995 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8920995 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8920995 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8920995 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:8920995 | pubmed:author | pubmed-author:TurnerA JAJ | lld:pubmed |
| pubmed-article:8920995 | pubmed:author | pubmed-author:HooperN MNM | lld:pubmed |
| pubmed-article:8920995 | pubmed:author | pubmed-author:ParkinE TET | lld:pubmed |
| pubmed-article:8920995 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8920995 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8920995 | pubmed:volume | 319 ( Pt 3) | lld:pubmed |
| pubmed-article:8920995 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8920995 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8920995 | pubmed:pagination | 887-96 | lld:pubmed |
| pubmed-article:8920995 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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