| pubmed-article:8916016 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8916016 | lifeskim:mentions | umls-concept:C0007301 | lld:lifeskim |
| pubmed-article:8916016 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:8916016 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:8916016 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:8916016 | lifeskim:mentions | umls-concept:C0079809 | lld:lifeskim |
| pubmed-article:8916016 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8916016 | pubmed:dateCreated | 1997-2-25 | lld:pubmed |
| pubmed-article:8916016 | pubmed:abstractText | Glycosaminoglycans (GAGs) are the main source of tissue fixed charge density (FCD) in cartilage, and are lost early in arthritic diseases. We tested the hypothesis that, like Na+, the charged contrast agent Gd-DTPA2- (and hence proton T1) could be used to measure tissue FCD and hence GAG concentration. NMR spectroscopy studies of cartilage explants demonstrated that there was a strong correlation (r > 0.96) between proton T1 in the presence of Gd-DTPA2- and tissue sodium and GAG concentrations. An ideal one-compartment electrochemical (Donnan) equilibrium model was examined as a means of quantifying FCD from Gd-DTPA2- concentration, yielding a value 50% less but linearly correlated with the validated method of quantifying FCD from Na+. These data could be used as the basis of an empirical model with which to quantify FCD from Gd-DTPA2- concentration, or a more sophisticated physical model could be developed. Spatial distributions of FCD were easily observed in T1-weighted MRI studies of trypsin and interleukin-1 induced cartilage degradation, with good histological correlation. Therefore, equilibration of the tissue in Gd-DTPA2- gives us the opportunity to directly image (through T1 weighting) the concentration of GAG, a major and critically important macromolecule in cartilage. Pilot clinical studies demonstrated Gd-DTPA2- penetration into cartilage, suggesting that this technique is clinically feasible. | lld:pubmed |
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| pubmed-article:8916016 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8916016 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8916016 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8916016 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8916016 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8916016 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8916016 | pubmed:issn | 0740-3194 | lld:pubmed |
| pubmed-article:8916016 | pubmed:author | pubmed-author:GrayM LML | lld:pubmed |
| pubmed-article:8916016 | pubmed:author | pubmed-author:BursteinDD | lld:pubmed |
| pubmed-article:8916016 | pubmed:author | pubmed-author:BashirAA | lld:pubmed |
| pubmed-article:8916016 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8916016 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:8916016 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8916016 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8916016 | pubmed:pagination | 665-73 | lld:pubmed |
| pubmed-article:8916016 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8916016 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8916016 | pubmed:articleTitle | Gd-DTPA2- as a measure of cartilage degradation. | lld:pubmed |
| pubmed-article:8916016 | pubmed:affiliation | Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, USA. | lld:pubmed |
| pubmed-article:8916016 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8916016 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8916016 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8916016 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8916016 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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