| pubmed-article:8915011 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C0625647 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C1705664 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C1285092 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C1333213 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C0205391 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8915011 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8915011 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:8915011 | pubmed:dateCreated | 1996-12-20 | lld:pubmed |
| pubmed-article:8915011 | pubmed:abstractText | We compared the expression of human alpha- and beta-defensins by various human tissues. mRNA for alpha-defensins HNP1-3, abundant in bone marrow, was detected in peripheral blood leukocytes, spleen and thymus by RT-PCR, which revealed alpha-defensins HD5 and HD6 only in the small intestine. In contrast, the pancreas and kidney expressed high levels of hBD-1 and lower levels of this beta-defensin were found in many organs by RT-PCR (salivary gland > trachea > prostate and placenta > thymus, testis, small intestine). hBD-1 mRNA was produced constitutively by cultured normal human epithelial cells derived from the trachea, bronchi, small airways and the mammary gland. These largely non-overlapping tissue distributions of human alpha- and beta-defensins suggest that hBD-1 may be positioned to defend epithelial cells and mucosae from infection, whereas expression of HNP1-3 in neutrophils and HD5 and HD6 in Paneth cells allows these alpha-defensins to participate in systemic and small intestinal host defenses, respectively. | lld:pubmed |
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| pubmed-article:8915011 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8915011 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8915011 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8915011 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8915011 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:8915011 | pubmed:author | pubmed-author:LehrerR IRI | lld:pubmed |
| pubmed-article:8915011 | pubmed:author | pubmed-author:WangII | lld:pubmed |
| pubmed-article:8915011 | pubmed:author | pubmed-author:ZhaoCC | lld:pubmed |
| pubmed-article:8915011 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8915011 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:8915011 | pubmed:volume | 396 | lld:pubmed |
| pubmed-article:8915011 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8915011 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8915011 | pubmed:pagination | 319-22 | lld:pubmed |
| pubmed-article:8915011 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8915011 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8915011 | pubmed:articleTitle | Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. | lld:pubmed |
| pubmed-article:8915011 | pubmed:affiliation | Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA. | lld:pubmed |
| pubmed-article:8915011 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8915011 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8915011 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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