| pubmed-article:8909255 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0699790 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0001516 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0596578 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0015272 | lld:lifeskim |
| pubmed-article:8909255 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8909255 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8909255 | pubmed:dateCreated | 1996-12-13 | lld:pubmed |
| pubmed-article:8909255 | pubmed:abstractText | It has been postulated that endothelial cell adhesion molecules involved in leukocyte recruitment play a role in metastasis. Using an in vitro flow model, we studied the adhesion of the human colon carcinoma cell line KM12-L4 to P-selectin, an inducible endothelial-expressed adhesion molecule involved in leukocyte recruitment. Recombinant forms of P-selectin and Chinese hamster ovary cells stably expressing P-selectin supported attachment and rolling of KM12-L4 cells at 1 to 2 dynes/cm2. The adhesive interactions to P-selectin were abolished by pretreatment of the KM12-L4 cells with neuraminidase but were unaltered by pretreatment of the KM12-L4 cells with O-sialoglycoprotein endopeptidase, an enzyme that cleaves mucin type glycoproteins such as P-selectin glycoprotein ligand-1 (PSGL-1). PSGL-1 is the only counter-receptor for P-selectin known to mediate myeloid cell adhesion to P-selectin under flow. Flow cytometric and Northern blot analyses revealed that KM12-L4 cells did not express PSGL-1 and monoclonal antibody PL1, a function-blocking monoclonal antibody to PSGL-1, had no inhibitory effect on KM12-L4 adhesion to P-selectin under flow. Compared with HL-60 cells, which express PSGL-1, the KM12-L4 cells exhibited a slightly lower rate of attachment to P-selectin and rolled at a significantly higher velocity. In summary, KM12-L4 human colon carcinoma cells interact with P-selectin, under flow, through a PSGL-1-independent adhesion pathway. | lld:pubmed |
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| pubmed-article:8909255 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8909255 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8909255 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8909255 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8909255 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8909255 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:8909255 | pubmed:author | pubmed-author:AtkinsonW JWJ | lld:pubmed |
| pubmed-article:8909255 | pubmed:author | pubmed-author:DingHH | lld:pubmed |
| pubmed-article:8909255 | pubmed:author | pubmed-author:LuscinskasF... | lld:pubmed |
| pubmed-article:8909255 | pubmed:author | pubmed-author:CummingD ADA | lld:pubmed |
| pubmed-article:8909255 | pubmed:author | pubmed-author:VachinoGG | lld:pubmed |
| pubmed-article:8909255 | pubmed:author | pubmed-author:CamphausenR... | lld:pubmed |
| pubmed-article:8909255 | pubmed:author | pubmed-author:GoetzD JDJ | lld:pubmed |
| pubmed-article:8909255 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8909255 | pubmed:volume | 149 | lld:pubmed |
| pubmed-article:8909255 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8909255 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8909255 | pubmed:pagination | 1661-73 | lld:pubmed |
| pubmed-article:8909255 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8909255 | pubmed:meshHeading | pubmed-meshheading:8909255-... | lld:pubmed |
| pubmed-article:8909255 | pubmed:meshHeading | pubmed-meshheading:8909255-... | lld:pubmed |
| pubmed-article:8909255 | pubmed:meshHeading | pubmed-meshheading:8909255-... | lld:pubmed |
| pubmed-article:8909255 | pubmed:meshHeading | pubmed-meshheading:8909255-... | lld:pubmed |
