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pubmed-article:8897994pubmed:dateCreated1996-12-16lld:pubmed
pubmed-article:8897994pubmed:abstractTextWe explored the possibility that quantitative analysis of the relationship between sucrose concentration and sham intake differentiated how various treatments affected the intake of sweet solutions. Rats were sham fed sucrose solutions varying in concentration from 0.03125 to 1.5 M. Under different treatment conditions, intake concentration functions were generated that plotted amount sham fed against sucrose concentration. Sucrose concentration that yielded 50% maximal sham intake were calculated to indicate the position of the concentration-intake function on the x-axis. Quinine adulteration of sucrose solutions and injection of 0.5 mg/kg i.p. of the dopamine antagonist pimozide reduced sham intake and shifted the concentration-intake function to the right. Lithium chloride (60 mg/kg i.p.) injected 30 min before sham feeding, a reduction of food deprivation from 18 to 6 h before sham feeding, and 6 micrograms/kg cholecystokinin octapeptide reduced sham intake equivalent amounts but did not shift the concentration-intake functions along the x-axis. The data indicate that of several factors that reduce sham feeding, only some also shift the position of concentration-intake curves, and these curve shifts may identify intake changes mediated by alterations in the processing of the taste input.lld:pubmed
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pubmed-article:8897994pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:8897994pubmed:year1996lld:pubmed
pubmed-article:8897994pubmed:articleTitleInterpretation of sham feeding data: curve-shift studies.lld:pubmed
pubmed-article:8897994pubmed:affiliationDepartment of Psychology, McMaster University, Hamilton, Ontario, Canada.lld:pubmed
pubmed-article:8897994pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8897994pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed