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pubmed-article:8897503pubmed:abstractTextDuring a previous investigation an association was found between major histocompatibility complex (MHC)-DRB1 alleles and faecal egg counts following natural infection predominantly involving Ostertagia circumcincta in a flock of Scottish Blackface sheep. To localise the disease-resistance locus we screened the same flock for an MHC class I microsatellite and a newly developed microsatellite for the DY locus located in the class IIb subregion. Some alleles at both additional loci were associated with resistance to infection. Least-squares analysis of variance indicated that in 6-month-old lambs, substitution of the most common alleles by the alleles associated with resistance would result in an 8- and a 218-fold reduction in faecal egg counts for MHC class I and DY, respectively. These results indicate that genes within the MHC genes play a large and significant role in the development of resistance to a widespread, important and natural parasite.lld:pubmed
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pubmed-article:8897503pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:8897503pubmed:articleTitleClass I and class II major histocompatibility complex alleles are associated with faecal egg counts following natural, predominantly Ostertagia circumcincta infection.lld:pubmed
pubmed-article:8897503pubmed:affiliationDepartment of Animal Breeding, Technical University Munich, Germany. buitkamp@pollux.edv.agrar.tu-muenchen.delld:pubmed
pubmed-article:8897503pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8897503pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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