| pubmed-article:8897167 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C0042762 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C0022877 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C0178932 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C1709793 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C2728259 | lld:lifeskim |
| pubmed-article:8897167 | lifeskim:mentions | umls-concept:C1318970 | lld:lifeskim |
| pubmed-article:8897167 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8897167 | pubmed:dateCreated | 1997-3-10 | lld:pubmed |
| pubmed-article:8897167 | pubmed:abstractText | A number of quantitative assays have been developed by using amplification techniques to measure human immunodeficiency virus type 1 RNA in the plasma of infected individuals. The Virology Committee of the AIDS Clinical Trials Group in the Division of AIDS, National Institute of Allergy and Infectious Diseases, has established a quality assurance program (QAP) for quantitative assays of HIV-1 RNA levels in plasma. The primary objective of the QAP was to ascertain that a laboratory could maintain the precision required to have a 90% power to detect a fivefold difference in RNA copy number between two samples in the same batch. To achieve this goal, the QAP required an intra-assay standard deviation of no greater than 0.15 log10 RNA copies per ml. Panels for proficiency testing consisted of coded replicate samples and a common set of standards. To date, 41 laboratories have participated in the program and have used both commercial and in-house assays. We demonstrated that 65% of the laboratories were capable of attaining the necessary level of intra-assay precision. The fitted regressions indicated that the differences among laboratories that used the same kit were generally greater than the differences among population-average regressions for the kits themselves. The use of an external QAP and a common set of standards reduced differences both among laboratories that used the same kit and among laboratories that used different kits. Thus, use of a common set of standards across clinical trial protocols would allow for cross-protocol comparisons. | lld:pubmed |
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| pubmed-article:8897167 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8897167 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8897167 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8897167 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8897167 | pubmed:issn | 0095-1137 | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:ToddJJ | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:BremerJJ | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:HermanSS | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:RasheedSS | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:JacksonBB | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:LiuH SHS | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:KatzensteinDD | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:CroninMM | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:Reichelderfer... | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:LeungSS | lld:pubmed |
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| pubmed-article:8897167 | pubmed:author | pubmed-author:Yen-Lieberman... | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:VaheyMM | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:CoombsRR | lld:pubmed |
| pubmed-article:8897167 | pubmed:author | pubmed-author:BrambillaDD | lld:pubmed |
| pubmed-article:8897167 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8897167 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:8897167 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8897167 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8897167 | pubmed:pagination | 2695-701 | lld:pubmed |
| pubmed-article:8897167 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8897167 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8897167 | pubmed:articleTitle | Evaluation of a quality assurance program for quantitation of human immunodeficiency virus type 1 RNA in plasma by the AIDS Clinical Trials Group virology laboratories. | lld:pubmed |
| pubmed-article:8897167 | pubmed:affiliation | Cleveland Clinic Foundation, University Hospitals of Cleveland, Ohio, USA. | lld:pubmed |
| pubmed-article:8897167 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8897167 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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