| pubmed-article:8892963 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8892963 | lifeskim:mentions | umls-concept:C0013485 | lld:lifeskim |
| pubmed-article:8892963 | lifeskim:mentions | umls-concept:C1518294 | lld:lifeskim |
| pubmed-article:8892963 | lifeskim:mentions | umls-concept:C0281666 | lld:lifeskim |
| pubmed-article:8892963 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8892963 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8892963 | pubmed:dateCreated | 1996-12-24 | lld:pubmed |
| pubmed-article:8892963 | pubmed:abstractText | P19 mouse embryonal carcinoma cells differentiate into neurons and glial cells when treated with retinoic acid. In contrast, a subline of the P19 cells, RAC65, is known to show little sign of differentiation with the treatment. We treated the two embryonal carcinoma (EC) cell lines with 9-cis-retinoic acid and investigated its neuron-inducing activity. In P19 cells, 9-cis-retinoic acid showed an activity equal to that of all-trans-retinoic acid. However in RAC65 cells, 9-cis-retinoic acid induced neurons 10-fold more effectively than all-trans-retinoic acid. The order in which various retinoids appeared in P19 cells corresponded to that of retinoic acid receptors, and the order in RAC65 cells to that of retinoid X receptors (RXRs). Furthermore we found that the down-regulation of retinoid X receptor-gamma mRNA expression was associated with neuronal differentiation in both embryonal carcinoma cell lines. In addition, a synthetic RXR-selective retinoid induced neurons from both EC cells. Our findings support an intriguing possibility that the 9-cis-retinoic acid/retinoid X receptor system may play an important role in neural differentiation. | lld:pubmed |
| pubmed-article:8892963 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8892963 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892963 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8892963 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8892963 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:8892963 | pubmed:author | pubmed-author:YokotaYY | lld:pubmed |
| pubmed-article:8892963 | pubmed:author | pubmed-author:OhkuboHH | lld:pubmed |
| pubmed-article:8892963 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8892963 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:8892963 | pubmed:volume | 228 | lld:pubmed |
| pubmed-article:8892963 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8892963 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8892963 | pubmed:pagination | 1-7 | lld:pubmed |
| pubmed-article:8892963 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8892963 | pubmed:meshHeading | pubmed-meshheading:8892963-... | lld:pubmed |
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| pubmed-article:8892963 | pubmed:meshHeading | pubmed-meshheading:8892963-... | lld:pubmed |
| pubmed-article:8892963 | pubmed:meshHeading | pubmed-meshheading:8892963-... | lld:pubmed |
| pubmed-article:8892963 | pubmed:meshHeading | pubmed-meshheading:8892963-... | lld:pubmed |
| pubmed-article:8892963 | pubmed:meshHeading | pubmed-meshheading:8892963-... | lld:pubmed |
| pubmed-article:8892963 | pubmed:meshHeading | pubmed-meshheading:8892963-... | lld:pubmed |
| pubmed-article:8892963 | pubmed:meshHeading | pubmed-meshheading:8892963-... | lld:pubmed |
| pubmed-article:8892963 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8892963 | pubmed:articleTitle | 9-cis-retinoic acid induces neuronal differentiation of retinoic acid-nonresponsive embryonal carcinoma cells. | lld:pubmed |
| pubmed-article:8892963 | pubmed:affiliation | Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan. | lld:pubmed |
| pubmed-article:8892963 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8892963 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8892963 | lld:pubmed |
