| pubmed-article:8892897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0030946 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C1553412 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C1548328 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8892897 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8892897 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8892897 | pubmed:dateCreated | 1996-12-30 | lld:pubmed |
| pubmed-article:8892897 | pubmed:abstractText | The enzymatic activity of the human immunodeficiency type 1 (HIV-1) protease (PR) is crucial to render HIV-1 virions mature and infectious. Hence, genetic intervention strategies based on trans-dominant (td) variants of the HIV-1 PR might be an alternative to current pharmacological and gene therapy regimens for AIDS. CD4-positive human CEM-SS T-cell lines were generated which constitutively expressed HIV-1 td PR variants. HIV-1 infection experiments demonstrated severely reduced HIV-1 replication in these td PR CEM-SS cell lines compared with control T cells expressing wild-type PR. Furthermore, replication of an HIV-1 isolate bearing a PR inhibitor-resistant PR was blocked, showing that genetic intervention strategies based on td PRs can be effective against HIV-1 isolates containing PR inhibitor-resistant mutants. | lld:pubmed |
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| pubmed-article:8892897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8892897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8892897 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8892897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8892897 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:8892897 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:BakerJJ | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:RoseJ RJR | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:CrainC RCR | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:EscaichSS | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:BöhnleinEE | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:McPheeFF | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:JunkerUU | lld:pubmed |
| pubmed-article:8892897 | pubmed:author | pubmed-author:PlavecII | lld:pubmed |
| pubmed-article:8892897 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8892897 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:8892897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8892897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8892897 | pubmed:pagination | 7765-72 | lld:pubmed |
| pubmed-article:8892897 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8892897 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8892897 | pubmed:articleTitle | Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines. | lld:pubmed |
| pubmed-article:8892897 | pubmed:affiliation | Progenesys Program at Systemix, Palo Alto, California 94304, USA. | lld:pubmed |
| pubmed-article:8892897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8892897 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8892897 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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