| pubmed-article:8890172 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8890172 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:8890172 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:8890172 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:8890172 | lifeskim:mentions | umls-concept:C0598306 | lld:lifeskim |
| pubmed-article:8890172 | lifeskim:mentions | umls-concept:C0805701 | lld:lifeskim |
| pubmed-article:8890172 | lifeskim:mentions | umls-concept:C1609990 | lld:lifeskim |
| pubmed-article:8890172 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:8890172 | pubmed:dateCreated | 1996-12-10 | lld:pubmed |
| pubmed-article:8890172 | pubmed:abstractText | Most homeodomains bind to DNA sequences containing the motif 5'-TAAT-3'. The homeodomain of thyroid transcription factor 1 (TTF-1HD) binds to sequences containing a 5'-CAAG-3' core motif, delineating a new mechanism for differential DNA recognition by homeodomains. We investigated the molecular basis of the DNA binding specificity of TTF-1HD by both structural and functional approaches. As already suggested by the three-dimensional structure of TTF-1HD, the DNA binding specificities of the TTF-1, Antennapedia and Engrailed homeodomains, either wild-type or mutants, indicated that the amino acid residue in position 54 is involved in the recognition of the nucleotide at the 3' end of the core motif 5'-NAAN-3'. The nucleotide at the 5' position of this core sequence is recognized by the amino acids located in position 6, 7 and 8 of the TTF-1 and Antennapedia homeodomains. These data, together with previous suggestions on the role of amino acids in position 50, indicate that the DNA binding specificity of homeodomains can be determined by a combinatorial molecular code. We also show that some specific combinations of the key amino acid residues involved in DNA recognition do not follow a simple, additive rule. | lld:pubmed |
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| pubmed-article:8890172 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8890172 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8890172 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8890172 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8890172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8890172 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8890172 | pubmed:issn | 0261-4189 | lld:pubmed |
