Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:8882589rdf:typepubmed:Citationlld:pubmed
pubmed-article:8882589lifeskim:mentionsumls-concept:C0151744lld:lifeskim
pubmed-article:8882589lifeskim:mentionsumls-concept:C0032468lld:lifeskim
pubmed-article:8882589lifeskim:mentionsumls-concept:C0035126lld:lifeskim
pubmed-article:8882589lifeskim:mentionsumls-concept:C0441472lld:lifeskim
pubmed-article:8882589lifeskim:mentionsumls-concept:C0439855lld:lifeskim
pubmed-article:8882589lifeskim:mentionsumls-concept:C0205171lld:lifeskim
pubmed-article:8882589lifeskim:mentionsumls-concept:C0389901lld:lifeskim
pubmed-article:8882589pubmed:issue6lld:pubmed
pubmed-article:8882589pubmed:dateCreated1996-12-11lld:pubmed
pubmed-article:8882589pubmed:abstractText1. The efficacy of oligotide, a single stranded polydeoxyribonucleotide complex, was examined in a feline model of myocardial ischaemia (MI: 90 min) and reperfusion (R: 270 min). Oligotide (15 mg kg-1 bolus) was administered intravenously 80 min after occlusion of the left anterior descending (LAD) coronary artery (i.e., 10 min prior to R) and continued for an additional 280 min (10 mg kg-1 h-1 infusion). 2. Oligotide-treated cats showed significantly smaller myocardial necroses and lower cardiac myeloperoxidase activities (significantly lower neutrophil infiltration) in the necrotic zone as compared to MI+R cats receiving only vehicle. 3. LAD coronary arteries isolated from MI+R cats exhibited a significant endothelial dysfunction (i.e., reduced endothelium-dependent relaxation), and significantly increased adherence of polymorphonuclear neutrophils (PMNs) ex vivo. However, oligotide significantly preserved endothelial function and attenuated PMN adherence in ischaemic LAD coronary arteries. 4. Oligotide attenuated P-selectin expression on thrombin-stimulated platelets as well as PMN adherence to thrombin-stimulated coronary endothelium. Immunohistochemical examination in vivo revealed that oligotide treatment also significantly inhibited coronary endothelial P-selectin expression after 90 min MI and 20 min R. 5. Oligotide exerted a significant cardioprotection in MI+R injury. The mechanism appears to be related to attenuation of PMN-endothelial interaction and eventual infiltration into the ischaemic myocardium.lld:pubmed
pubmed-article:8882589pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:languageenglld:pubmed
pubmed-article:8882589pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:citationSubsetIMlld:pubmed
pubmed-article:8882589pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:8882589pubmed:statusMEDLINElld:pubmed
pubmed-article:8882589pubmed:monthMarlld:pubmed
pubmed-article:8882589pubmed:issn0007-1188lld:pubmed
pubmed-article:8882589pubmed:authorpubmed-author:LeferA MAMlld:pubmed
pubmed-article:8882589pubmed:authorpubmed-author:MuroharaTTlld:pubmed
pubmed-article:8882589pubmed:authorpubmed-author:BuerkeMMlld:pubmed
pubmed-article:8882589pubmed:issnTypePrintlld:pubmed
pubmed-article:8882589pubmed:volume117lld:pubmed
pubmed-article:8882589pubmed:ownerNLMlld:pubmed
pubmed-article:8882589pubmed:authorsCompleteYlld:pubmed
pubmed-article:8882589pubmed:pagination1000-8lld:pubmed
pubmed-article:8882589pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:meshHeadingpubmed-meshheading:8882589-...lld:pubmed
pubmed-article:8882589pubmed:year1996lld:pubmed
pubmed-article:8882589pubmed:articleTitleCardioprotective actions of oligotide, a single stranded polydeoxyribonucleotide complex, in myocardial ischaemia and reperfusion injury.lld:pubmed
pubmed-article:8882589pubmed:affiliationDepartment of Physiology, Thomas Jefferson University, Philadelphia, PA 19107-6799, USA.lld:pubmed
pubmed-article:8882589pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8882589pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:8882589pubmed:publicationTypeIn Vitrolld:pubmed
More...