| pubmed-article:8879206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C0125090 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C1334146 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C0169362 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C0205463 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:8879206 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8879206 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8879206 | pubmed:dateCreated | 1996-12-13 | lld:pubmed |
| pubmed-article:8879206 | pubmed:abstractText | Naive T cells are selectively recruited from the blood into peripheral lymph nodes during lymphocyte recirculation. L-selectin, a lectin-like receptor, mediates the initial attachment of lymphocytes to high endothelial venules (HEV) in lymph nodes. A subsequent step involving the activation of beta 2 integrins has been proposed to facilitate firm adhesion, but the activating signals are poorly understood. We report here that either antibody-mediated cross-linking of L-selectin on human lymphocytes or treatment of the cells with GlyCAM-1, an HEV-derived, secreted ligand for L-selectin, stimulates their binding to ICAM-1 through the beta 2 integrin pathway. Furthermore, GlyCAM-1 causes the rapid expression of a neoepitope on beta 2 integrins associated with a high-avidity state. Naive (CD45RA+), but not memory (CD45R0+) lymphocytes, respond to L-selectin cross-linking or GlyCAM-1 treatment. Thus, the complexing of L-selectin by specific ligands may provide key signals to naive lymphocytes, contributing to their selective recruitment into peripheral lymphoid organs. | lld:pubmed |
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| pubmed-article:8879206 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8879206 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8879206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8879206 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8879206 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:8879206 | pubmed:author | pubmed-author:RosenS DSD | lld:pubmed |
| pubmed-article:8879206 | pubmed:author | pubmed-author:SingerM SMS | lld:pubmed |
| pubmed-article:8879206 | pubmed:author | pubmed-author:SimonS ISI | lld:pubmed |
| pubmed-article:8879206 | pubmed:author | pubmed-author:YednockT ATA | lld:pubmed |
| pubmed-article:8879206 | pubmed:author | pubmed-author:HwangS TST | lld:pubmed |
| pubmed-article:8879206 | pubmed:author | pubmed-author:GiblinP APA | lld:pubmed |
| pubmed-article:8879206 | pubmed:author | pubmed-author:BaconK BKB | lld:pubmed |
| pubmed-article:8879206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8879206 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8879206 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:8879206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8879206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8879206 | pubmed:pagination | 1343-8 | lld:pubmed |
| pubmed-article:8879206 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8879206 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8879206 | pubmed:articleTitle | GlyCAM-1, a physiologic ligand for L-selectin, activates beta 2 integrins on naive peripheral lymphocytes. | lld:pubmed |
| pubmed-article:8879206 | pubmed:affiliation | Department of Anatomy and Program in Immunology, University of California, San Francisco 94143, USA. | lld:pubmed |
| pubmed-article:8879206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8879206 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8879206 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8879206 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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