| pubmed-article:8876179 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C0009207 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C0035679 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C1519751 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:8876179 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8876179 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:8876179 | pubmed:dateCreated | 1996-12-4 | lld:pubmed |
| pubmed-article:8876179 | pubmed:abstractText | Damage to actively transcribed DNA is preferentially repaired by the transcription-coupled repair (TCR) system. TCR requires RNA polymerase II (Pol II), but the mechanism by which repair enzymes preferentially recognize and repair DNA lesions on Pol II-transcribed genes is incompletely understood. Herein we demonstrate that a fraction of the large subunit of Pol II (Pol II LS) is ubiquitinated after exposing cells to UV-radiation or cisplatin but not several other DNA damaging agents. This novel covalent modification of Pol II LS occurs within 15 min of exposing cells to UV-radiation and persists for about 8-12 hr. Ubiquitinated Pol II LS is also phosphorylated on the C-terminal domain. UV-induced ubiquitination of Pol II LS is deficient in fibroblasts from individuals with two forms of Cockayne syndrome (CS-A and CS-B), a rare disorder in which TCR is disrupted. UV-induced ubiquitination of Pol II LS can be restored by introducing cDNA constructs encoding the CSA or CSB genes, respectively, into CS-A or CS-B fibroblasts. These results suggest that ubiquitination of Pol II LS plays a role in the recognition and/or repair of damage to actively transcribed genes. Alternatively, these findings may reflect a role played by the CSA and CSB gene products in transcription. | lld:pubmed |
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| pubmed-article:8876179 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8876179 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876179 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8876179 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8876179 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8876179 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8876179 | pubmed:author | pubmed-author:HalabanRR | lld:pubmed |
| pubmed-article:8876179 | pubmed:author | pubmed-author:WarrenS LSL | lld:pubmed |
| pubmed-article:8876179 | pubmed:author | pubmed-author:FriedbergE... | lld:pubmed |
| pubmed-article:8876179 | pubmed:author | pubmed-author:BregmanD BDB | lld:pubmed |
| pubmed-article:8876179 | pubmed:author | pubmed-author:HenningK AKA | lld:pubmed |
| pubmed-article:8876179 | pubmed:author | pubmed-author:van GoolA JAJ | lld:pubmed |
| pubmed-article:8876179 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8876179 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8876179 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8876179 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8876179 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8876179 | pubmed:pagination | 11586-90 | lld:pubmed |
| pubmed-article:8876179 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8876179 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8876179 | pubmed:articleTitle | UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells. | lld:pubmed |
| pubmed-article:8876179 | pubmed:affiliation | Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA. bregman@aecom.yu.edu | lld:pubmed |
| pubmed-article:8876179 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8876179 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8876179 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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