| pubmed-article:8876043 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0699762 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0014180 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0030095 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0033308 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8876043 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8876043 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8876043 | pubmed:dateCreated | 1997-1-21 | lld:pubmed |
| pubmed-article:8876043 | pubmed:abstractText | The effects of recombinant ovine interferon-tau (IFN-tau) and progesterone on oestrogen-stimulated expression of endometrial receptors for oestrogen (ER), progesterone (PR) and oxytocin (OTR) were determined in ovariectomized ewes. Cyclic ewes (n = 16) were ovariectomized and fitted with uterine catheters on Day 4 of the oestrous cycle (Day O, oestrous) and assigned randomly in 2 x 2-factorial arrangement to receive daily intrauterine injections of either recombinant ovine IFN-tau (roIFN-tau; 2 x 10(7) anti-viral units) or control proteins from Day 11 to Day 15 and 50 mg progesterone from either Day 4 to Day 10 (E-P) or Day 4 to Day 15 (E+P). All ewes received 50 micrograms oestradiol-17 beta on Days 13, 14 and 15 and were hysterectomized on Day 16. In control ewes, endometrial ER mRNA, PR protein and OTR density were greater in E-P- than E+P- treated ewes. In E-P ewes, roIFN-tau decreased oestrogen-stimulated increases in ER and OTR, but not PR expression compared with control ewes. In E+P ewes, endometrial ER mRNA and protein, PR mRNA and protein, and OTR levels were lower in roIFN-tau-treated ewes than control ewes. Immunoreactive ER and PR were absent in the endometrial luminal and superficial glandular epithelium of roIFN-tau compared with control ewes, but were present in the deep glandular epithelium and stroma regardless of steroid or protein treatment. These results indicate that progesterone affects oestrogen-induced increases in endometrial ER, PR and OTR expression in the PR+ deep glandular epithelium and stroma, whereas IFN-tau suppresses oestrogen-induced increases ER, PR and OTR expression in the PR- luminal and superficial glandular epithelium. These combined actions of IFN-tau and progesterone to suppress oestrogen-induced increases in endometrial OTR formation would prevent pulsatile production of luteolytic prostaglandin F2 alpha by the endometrium during early pregnancy. | lld:pubmed |
| pubmed-article:8876043 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8876043 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8876043 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8876043 | pubmed:issn | 1031-3613 | lld:pubmed |
| pubmed-article:8876043 | pubmed:author | pubmed-author:BazerF WFW | lld:pubmed |
| pubmed-article:8876043 | pubmed:author | pubmed-author:YenY TYT | lld:pubmed |
| pubmed-article:8876043 | pubmed:author | pubmed-author:MayerJ RJR | lld:pubmed |
| pubmed-article:8876043 | pubmed:author | pubmed-author:WatsonG HGH | lld:pubmed |
| pubmed-article:8876043 | pubmed:author | pubmed-author:MirandoM AMA | lld:pubmed |
| pubmed-article:8876043 | pubmed:author | pubmed-author:SpencerT ETE | lld:pubmed |
| pubmed-article:8876043 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8876043 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:8876043 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8876043 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8876043 | pubmed:pagination | 843-53 | lld:pubmed |
| pubmed-article:8876043 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8876043 | pubmed:meshHeading | pubmed-meshheading:8876043-... | lld:pubmed |
| pubmed-article:8876043 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8876043 | pubmed:articleTitle | Effects of interferon-tau and progesterone on oestrogen-stimulated expression of receptors for oestrogen, progesterone and oxytocin in the endometrium of ovariectomized ewes. | lld:pubmed |
| pubmed-article:8876043 | pubmed:affiliation | Department of Animal Science, Texas A&M University, College Station 77843-2471, USA. | lld:pubmed |
| pubmed-article:8876043 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8876043 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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