Linked Life Data

8871667

Source:http://linkedlifedata.com/resource/pubmed/id/8871667

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pubmed-article:8871667pubmed:abstractTextAnimal models of HIV-1 have a key role to play in elucidation of the cellular mechanisms responsible for protective immunity. Vaccination of domestic cats with whole inactivated feline immunodeficiency virus (FIV) elicits virus-neutralizing Abs and virus-specific CTL in the peripheral blood and lymphoid organs and affords protection from homologous virus challenge. In the present study we confirm the induction of virus-specific CTL following immunization with whole inactivated FIV vaccine and demonstrate that cats are protected for up to 1 yr following vaccination. Long term protection in vaccinated cats correlates with both higher levels of FIV Env-specific CTL in the peripheral blood following vaccination and the presence of FIV Env-specific memory CD8+ CTL in the lymph nodes, which persist for up to 1 yr following challenge in the absence of detectable virus. The CTL responses observed in vaccinated protected cats differ qualitatively from those in FIV-infected cats. The latter cats either do not generate a memory CTL response or exhibit a Gag-specific memory CTL response. These results show that the protective immunity observed in whole inactivated virus-vaccinated cats is associated with the induction of high levels of Env-specific CTL activity.lld:pubmed
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pubmed-article:8871667pubmed:articleTitleEnv-specific CTL predominate in cats protected from feline immunodeficiency virus infection by vaccination.lld:pubmed
pubmed-article:8871667pubmed:affiliationDepartment of Veterinary Pathology, University of Glasgow, Bearsden, Scotland.lld:pubmed
pubmed-article:8871667pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8871667pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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