| pubmed-article:8865203 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8865203 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:8865203 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:8865203 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:8865203 | lifeskim:mentions | umls-concept:C1518294 | lld:lifeskim |
| pubmed-article:8865203 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:8865203 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:8865203 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8865203 | pubmed:dateCreated | 1997-1-6 | lld:pubmed |
| pubmed-article:8865203 | pubmed:abstractText | Neurotrophic effects of estradiol and insulin-like growth factor-I were assessed in primary cultures from fetal rat hypothalamus. Cultured neurons were immunostained with an antibody for the microtubule-associated protein-2. While both estradiol and insulin-like growth factor-I increased the number of microtubule-associated protein-2-immunoreactive neurons and the extension of immunoreactive processes, the effect of these two factors was not additive. The estradiol-induced increases in neuronal numbers and extension of neuronal processes were blocked by either the estrogen receptor antagonist ICI 182,780 or by an anti-sense oligonucleotide to the estrogen receptor. Furthermore, incubation of the cultures with an anti-sense oligonucleotide directed against the insulin-like growth factor-I messenger RNA also blocked the effect of estradiol. In turn, the effects of insulin-like growth factor-I were blocked by the estrogen receptor antagonist ICI 182,780 and by the anti-sense oligonucleotide to the estrogen receptor. These findings suggest that estradiol-induced activation of the estrogen receptor in developing hypothalamic cells requires the presence of insulin-like growth factor-I, and that both estradiol and insulin-like growth factor-I use the estrogen receptor as a mediator of their trophic effects on hypothalamic neurons. | lld:pubmed |
| pubmed-article:8865203 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8865203 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8865203 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8865203 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8865203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8865203 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8865203 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8865203 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8865203 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:8865203 | pubmed:author | pubmed-author:NaftolinFF | lld:pubmed |
| pubmed-article:8865203 | pubmed:author | pubmed-author:Garcia-Segura... | lld:pubmed |
| pubmed-article:8865203 | pubmed:author | pubmed-author:Torres-Aleman... | lld:pubmed |
| pubmed-article:8865203 | pubmed:author | pubmed-author:DuenasMM | lld:pubmed |
| pubmed-article:8865203 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8865203 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:8865203 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8865203 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8865203 | pubmed:pagination | 531-9 | lld:pubmed |
| pubmed-article:8865203 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:meshHeading | pubmed-meshheading:8865203-... | lld:pubmed |
| pubmed-article:8865203 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8865203 | pubmed:articleTitle | Interaction of insulin-like growth factor-I and estradiol signaling pathways on hypothalamic neuronal differentiation. | lld:pubmed |
| pubmed-article:8865203 | pubmed:affiliation | Instituto Cajal, C.S.I.C., Madrid, Spain. | lld:pubmed |
| pubmed-article:8865203 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8865203 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8865203 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8865203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8865203 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8865203 | lld:pubmed |
