| pubmed-article:8864571 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C1383501 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C0006100 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:8864571 | lifeskim:mentions | umls-concept:C0242842 | lld:lifeskim |
| pubmed-article:8864571 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8864571 | pubmed:dateCreated | 1996-12-16 | lld:pubmed |
| pubmed-article:8864571 | pubmed:abstractText | In this study we have monitored the change of intracellular Ca2+ concentrations in the cytosol ([Ca2+]c) and the mitochondria ([Ca2+]m) of single bovine endothelial cells following treatment with bradykinin (BK). Using laser scanning confocal microscopy, we have found that the Ca2+ indicator, Fluo-3, is compartmentalized in the mitochondria of endothelial cells loaded with Fluo-3/AM. After BK stimulation, the pattern of Ca2+ increase in the cytosol is different from that in the mitochondria. The amplitude of the Ca2+ rise in the mitochondria is higher than that in the cytosol. Further analysis using rapid scanning measurements indicates that the [Ca2+]c increase is very fast after BK addition and reaches a maxima level within 400 ms. In contrast, the [Ca2+]m increase appears to be biphasic with an initial rapid increase (concomitant with the [Ca2+]c increase) followed by a slower [Ca2+]m increase before reaching a maximal level (within 5 s of BK treatment). The differential Ca2+ signaling pattern between the cytosol and the mitochondria suggests that the intracellular Ca2+ concentrations needed to regulate various Ca(2+)-dependent enzymes located in these two compartments are different during BK-induced endothelial cell activation. | lld:pubmed |
| pubmed-article:8864571 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8864571 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8864571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8864571 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8864571 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8864571 | pubmed:issn | 0143-4160 | lld:pubmed |
| pubmed-article:8864571 | pubmed:author | pubmed-author:BourguignonL... | lld:pubmed |
| pubmed-article:8864571 | pubmed:author | pubmed-author:DonnadieuEE | lld:pubmed |
| pubmed-article:8864571 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8864571 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:8864571 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8864571 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8864571 | pubmed:pagination | 53-61 | lld:pubmed |
| pubmed-article:8864571 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8864571 | pubmed:meshHeading | pubmed-meshheading:8864571-... | lld:pubmed |
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| pubmed-article:8864571 | pubmed:meshHeading | pubmed-meshheading:8864571-... | lld:pubmed |
| pubmed-article:8864571 | pubmed:meshHeading | pubmed-meshheading:8864571-... | lld:pubmed |
| pubmed-article:8864571 | pubmed:meshHeading | pubmed-meshheading:8864571-... | lld:pubmed |
| pubmed-article:8864571 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8864571 | pubmed:articleTitle | Ca2+ signaling in endothelial cells stimulated by bradykinin: Ca2+ measurement in the mitochondria and the cytosol by confocal microscopy. | lld:pubmed |
| pubmed-article:8864571 | pubmed:affiliation | Department of Cell Biology and Anatomy, University of Miami Medical School, Florida 33101, USA. | lld:pubmed |
| pubmed-article:8864571 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8864571 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8864571 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8864571 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8864571 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8864571 | lld:pubmed |
