| pubmed-article:8855313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0077503 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0872054 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:8855313 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:8855313 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:8855313 | pubmed:dateCreated | 1996-11-25 | lld:pubmed |
| pubmed-article:8855313 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8855313 | pubmed:abstractText | Latent infection membrane protein 1 (LMP1), the Epstein-Barr virus transforming protein, associates with tumor necrosis factor receptor (TNFR) associated factor 1 (TRAF1) and TRAF3. Since TRAF2 has been implicated in TNFR-mediated NF-kappa B activation, we have evaluated the role of TRAF2 in LMP1-mediated NF-kappa B activation. TRAF2 binds in vitro to the LMP1 carboxyl-terminal cytoplasmic domain (CT), coprecipitates with LMP1 in B lymphoblasts, and relocalizes to LMP1 plasma membrane patches. A dominant negative TRAF2 deletion mutant that lacks amino acids 6-86 (TRAF/ delta 6-86) inhibits NF-kappa B activation from the LMP1 CT and competes with TRAF2 for LMP1 binding. TRAF2 delta 6-86 inhibits NF-kappa B activation mediated by the first 45 amino acids of the LMP1 CT by more than 75% but inhibits NF-kappa B activation through the last 55 amino acids of the CT by less than 40%. A TRAF interacting protein, TANK, inhibits NF-kappa B activation by more than 70% from both LMP1 CT domains. These data implicate TRAF2 aggregation in NF-kappa B activation by the first 45 amino acids of the LMP1 CT and suggest that a different TRAF-related pathway may be involved in NF-kappa B activation by the last 55 amino acids of the LMP1 CT. | lld:pubmed |
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| pubmed-article:8855313 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8855313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8855313 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8855313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8855313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8855313 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8855313 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:8855313 | pubmed:author | pubmed-author:KieffEE | lld:pubmed |
| pubmed-article:8855313 | pubmed:author | pubmed-author:DevergneOO | lld:pubmed |
| pubmed-article:8855313 | pubmed:author | pubmed-author:MosialosGG | lld:pubmed |
| pubmed-article:8855313 | pubmed:author | pubmed-author:KayeK MKM | lld:pubmed |
| pubmed-article:8855313 | pubmed:author | pubmed-author:IzumiK MKM | lld:pubmed |
| pubmed-article:8855313 | pubmed:author | pubmed-author:YalamanchiliR... | lld:pubmed |
| pubmed-article:8855313 | pubmed:author | pubmed-author:HaradaJ NJN | lld:pubmed |
| pubmed-article:8855313 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8855313 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8855313 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:8855313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8855313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8855313 | pubmed:pagination | 11085-90 | lld:pubmed |
| pubmed-article:8855313 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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