| pubmed-article:8831785 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0525009 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0007637 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C2936473 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0079866 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:8831785 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8831785 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8831785 | pubmed:dateCreated | 1996-11-7 | lld:pubmed |
| pubmed-article:8831785 | pubmed:abstractText | The maltose-binding protein (MBP) of Escherichia coli is the periplasmic receptor of the maltose transport system. Previous studies have identified amino acid substitutions in an alpha/beta loop of the structure of MBP that are critical for the in vivo folding. To probe genetically the structural role of this surface loop, we generated a library in which the corresponding codons 32 and 33 of malE were mutagenized. The maltose phenotype, which correlates with a biologically active structure of MBP in the periplasm, indicated a considerable variability in the loop residues compatible with a correct in vivo folding pathway of the protein. By the same genetic screens, we characterized loop-variant MBPs associated with a defective periplasmic folding pathway and aggregated into inclusion bodies. Heat-shock induction with production of misfolded loop variants was examined using both lon-lacZ and htrA-lacZ fusions. We found that the extent of formation of inclusion bodies in the periplasm of E. coli, from misfolded loop variant MBPs, correlated with the level of heat-shock response regulated by the alternate heat-shock sigma factor, sigma 24. | lld:pubmed |
| pubmed-article:8831785 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8831785 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8831785 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8831785 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8831785 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:8831785 | pubmed:author | pubmed-author:HofnungMM | lld:pubmed |
| pubmed-article:8831785 | pubmed:author | pubmed-author:RainaSS | lld:pubmed |
| pubmed-article:8831785 | pubmed:author | pubmed-author:BettonJ MJM | lld:pubmed |
| pubmed-article:8831785 | pubmed:author | pubmed-author:MissiakasDD | lld:pubmed |
| pubmed-article:8831785 | pubmed:author | pubmed-author:BoscusDD | lld:pubmed |
| pubmed-article:8831785 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8831785 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:8831785 | pubmed:volume | 262 | lld:pubmed |
| pubmed-article:8831785 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8831785 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8831785 | pubmed:pagination | 140-50 | lld:pubmed |
| pubmed-article:8831785 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8831785 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8831785 | pubmed:articleTitle | Probing the structural role of an alpha beta loop of maltose-binding protein by mutagenesis: heat-shock induction by loop variants of the maltose-binding protein that form periplasmic inclusion bodies. | lld:pubmed |
| pubmed-article:8831785 | pubmed:affiliation | Départment des Biotechnologies, Institut Pasteur, Paris, France. | lld:pubmed |
| pubmed-article:8831785 | pubmed:publicationType | Journal Article | lld:pubmed |
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