| pubmed-article:8828501 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8828501 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:8828501 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:8828501 | pubmed:dateCreated | 1996-12-18 | lld:pubmed |
| pubmed-article:8828501 | pubmed:abstractText | Developmental studies of oncogene expression implicate the Fos and Jun family of transcription factors in the regulation of bone growth and differentiation. Promoters of many developmentally regulated genes, including osteocalcin, a marker of osteoblast differentiation, contain AP-1 sites that bind Fos/Jun dimers. Here, we demonstrate that the selective expression of fos- and jun-related genes is functionally related to the stage of osteoblast growth and differentiation in vitro. During osteoblast proliferation, nuclear protein levels of all seven activating protein-1 (AP-1) members are maximal. Subsequently, during the period of extracellular matrix maturation, levels decline. In fully differentiated osteoblasts, Fra-2 and (to a lesser extent) Jun D are the principal AP-1 members detectable by Western blot analysis. AP-1 complex composition and binding activity also exhibit developmental changes. All Fos and Jun family members are involved in AP-1 complex formation in proliferating cells, whereas Fra-2 and Jun D predominate in AP-1 complexes in differentiated osteoblasts. Overexpression of Fos and Jun family members in ROS 17/2.8 cells markedly affects the expression of an osteocalcin promoter-chloramphenicol acetyltransferase construct. Coexpression of only one AP-1 pair, Fra-2 and Jun D, stimulated reporter expression, whereas coexpression of other AP-1 pairs down-regulated expression (i.e. c-jun and any Fos family member) or had no effect (i.e. Fra-1 and Jun B). Promoter deletion analyses indicate that these effects are site specific. Consequential effects of Fra-2 on osteoblast differentiation are further demonstrated by antisense studies in which osteoblast differentiation and the development of a bone tissue-like organization were suppressed. Consistent with recent findings suggesting that AP-1 complex composition can selectively regulate gene transcription, our findings demonstrate that differential expression of Fos and Jun family members could play a role in the developmental regulation of bone-specific gene expression and, as a result, may be functionally significant for osteoblast differentiation. | lld:pubmed |
| pubmed-article:8828501 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8828501 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8828501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8828501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8828501 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8828501 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8828501 | pubmed:issn | 0013-7227 | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:LiaoJ CJC | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:SteimJ MJM | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:SteinG SGS | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:HarrisonR JRJ | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:DobnerP RPR | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:BanerjeeCC | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:KundeBB | lld:pubmed |
| pubmed-article:8828501 | pubmed:author | pubmed-author:McCabeL RLR | lld:pubmed |
| pubmed-article:8828501 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8828501 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:8828501 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8828501 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8828501 | pubmed:pagination | 4398-408 | lld:pubmed |
| pubmed-article:8828501 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8828501 | pubmed:meshHeading | pubmed-meshheading:8828501-... | lld:pubmed |
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| pubmed-article:8828501 | pubmed:meshHeading | pubmed-meshheading:8828501-... | lld:pubmed |
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| pubmed-article:8828501 | pubmed:meshHeading | pubmed-meshheading:8828501-... | lld:pubmed |
| pubmed-article:8828501 | pubmed:meshHeading | pubmed-meshheading:8828501-... | lld:pubmed |
| pubmed-article:8828501 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8828501 | pubmed:articleTitle | Developmental expression and activities of specific fos and jun proteins are functionally related to osteoblast maturation: role of Fra-2 and Jun D during differentiation. | lld:pubmed |
| pubmed-article:8828501 | pubmed:affiliation | Department of Cell Biology, University of Massachusetts Medical Center, Worcester 01655, USA. | lld:pubmed |
| pubmed-article:8828501 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8828501 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8828501 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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