| pubmed-article:8827214 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C0032868 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C0019707 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C0024400 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1514798 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1511253 | lld:lifeskim |
| pubmed-article:8827214 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:8827214 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:8827214 | pubmed:dateCreated | 1997-1-2 | lld:pubmed |
| pubmed-article:8827214 | pubmed:abstractText | Vaccine protocols involving multiple immunizations with molecularly attenuated vaccinia virus (NYVAC) or naturally attenuated canarypox virus (ALVAC) HIV-2 recombinants and subunit boosts have conferred longlasting protection against HIV-2 infection of macaques. Similar complex protocols using HIV-1 NYVAC and ALVAC recombinants and subunit boosts have provided cross-protection against HIV-2 challenge. Here a simplified three-immunization regimen over 24 weeks was tested in 18 juvenile rhesus macaques. Twelve macaques were immunized twice with NYVAC or ALVAC recombinants carrying HIV-2 env, gag, and pol genes. Subsequently, macaques in groups of three received either an additional recombinant immunization or an HIV-2 gp160 boost. Six control macaques received three immunizations of NYVAC or ALVAC vector alone and additionally alum at the third immunization. Macaques primed with ALVAC recombinant exhibited sporadic T cell proliferative activity, and all but one failed to develop neutralizing antibodies. In contrast, macaques primed with NYVAC recombinants had no T cell proliferative activity but exhibited neutralizing antibody titers (highest in the three recombinant group) that declined by the time of challenge. None of the macaques exhibited significant cytotoxic T lymphocyte activity. Following challenge at 32 weeks with HIV-2SBL6669 all macaques became infected. Thus, the three-immunization regimen is not sufficient to confer protective immunity in the HIV-2 rhesus macaque model. However, delayed infection in macaques immunized with the NYVAC-HIV-2 recombinant may have been associated with the development of memory B cells capable of providing a neutralizing antibody response on challenge. | lld:pubmed |
| pubmed-article:8827214 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8827214 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8827214 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8827214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8827214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8827214 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8827214 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8827214 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8827214 | pubmed:issn | 0889-2229 | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:GalloR CRC | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:Robert-Guroff... | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:MarkhamP DPD | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:FranchiniGG | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:PaolettiEE | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:TartagliaJJ | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:MyagkikhMM | lld:pubmed |
| pubmed-article:8827214 | pubmed:author | pubmed-author:AlipanahSS | lld:pubmed |
| pubmed-article:8827214 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8827214 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:8827214 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:8827214 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8827214 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8827214 | pubmed:pagination | 985-92 | lld:pubmed |
| pubmed-article:8827214 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:8827214 | pubmed:meshHeading | pubmed-meshheading:8827214-... | lld:pubmed |
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| pubmed-article:8827214 | pubmed:meshHeading | pubmed-meshheading:8827214-... | lld:pubmed |
| pubmed-article:8827214 | pubmed:meshHeading | pubmed-meshheading:8827214-... | lld:pubmed |
| pubmed-article:8827214 | pubmed:meshHeading | pubmed-meshheading:8827214-... | lld:pubmed |
| pubmed-article:8827214 | pubmed:meshHeading | pubmed-meshheading:8827214-... | lld:pubmed |
| pubmed-article:8827214 | pubmed:meshHeading | pubmed-meshheading:8827214-... | lld:pubmed |
| pubmed-article:8827214 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8827214 | pubmed:articleTitle | Multiple immunizations with attenuated poxvirus HIV type 2 recombinants and subunit boosts required for protection of rhesus macaques. | lld:pubmed |
| pubmed-article:8827214 | pubmed:affiliation | Laboratory of Tumor Cell Biology, DBS, NCI, NIH, Bethesda, Maryland 20892-4255, USA. | lld:pubmed |
| pubmed-article:8827214 | pubmed:publicationType | Journal Article | lld:pubmed |
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